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Pseudomonas exotoxin

Exotoxin produced by Pseudomonas aeruginosa

Summary

Exotoxin produced by Pseudomonas aeruginosa

Field	Value
image	1aer.jpg
caption	Exotoxin A dimer, Pseudomonas aeruginosa
ECnumber	2.4.2.36
Organism	Pseudomonas aeruginosa
Name	Exotoxin A
Symbol	eta
UniProt	P11439

The Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa. Vibrio cholerae produces a similar protein called the Cholix toxin ().

It inhibits elongation factor-2. It does so by ADP-ribosylation of EF2 using NAD+. This then causes the elongation of polypeptides to cease. This mechanism is similar to that of diphtheria toxin.

It has been investigated as a treatment for hepatitis B and cancer.

References

(February 2005). "Structure-function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa". The Biochemical Journal.
(April 2008). "Cholix toxin, a novel ADP-ribosylating factor from Vibrio cholerae". The Journal of Biological Chemistry.
(May 2004). "Elucidation of eukaryotic elongation factor-2 contact sites within the catalytic domain of Pseudomonas aeruginosa exotoxin A". The Biochemical Journal.
(May 2008). "Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells". World Journal of Gastroenterology.
(February 2015). "Engineering toxin-resistant therapeutic stem cells to treat brain tumors". Stem Cells.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

bacterial-toxins proteins

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