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Pseudoangiomatous stromal hyperplasia

Field	Value
name	Pseudoangiomatous stromal hyperplasia
image	Pseudoangiomatous stromal hyperplasia - high mag.jpg
caption	High magnification micrograph of pseudoangiomatous stromal hyperplasia showing the characteristic small, anastomosing blood vessel-like channels. H&E stain.
field	Pathology

Pseudoangiomatous stromal hyperplasia (PASH) is an overgrowth of myofibroblastic cells in the breast. It has an appearance similar to fibroadenomatoid changes.

The diagnostic significance is currently uncertain, but it appears to be benign. There have been cases of PASH diagnosed where the tumors co-exist with breast cancer. Other cases have made screening for breast cancer difficult and in some cases impossible due to the number and density of the existing PASH tumors. These cases have resulted in the necessity of a mastectomy and double mastectomy.

Diagnosis

The diagnosis of PASH is by biopsy.

The important differential diagnosis is angiosarcoma, from which it was first differentiated in 1986.

Differential diagnosis

Fibroadenoma
Angiosarcoma

Treatment

The management of PASH is controversial. Excision may be indicated in enlarging masses or lesions with atypical features.

References

(March 1995). "Pseudoangiomatous stromal hyperplasia (PASH). A mammary stromal tumor with myofibroblastic differentiation". Am. J. Surg. Pathol..
(February 1986). "Pseudoangiomatous hyperplasia of mammary stroma". Hum. Pathol..
(December 1997). "Pseudoangiomatous hyperplasia of mammary stroma in an HIV patient". Gen Diagn Pathol.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

breast-diseases

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