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Protein Z-related protease inhibitor

Field	Value
caption	Crystal structure of protein Z-dependent peptidase inhibitor (red) in complex with protein Z (blue). Rendered from PDB 3F1S
image	3F1S.png
HGNCid	15996
Symbol	SERPINA10
EntrezGene	51156
OMIM	605271
RefSeq	NM_016186
UniProt	Q9UK55
Chromosome	14
Arm	q
Band	32.1

Protein Z-dependent protease inhibitor (ZPI) is a protein circulating in the blood which inhibits factors Xa and XIa of the coagulation cascade. It is a member of the class of the serine protease inhibitors (serpins). Its name implies that it requires protein Z, another circulating protein, to function properly, but this only applies to its inhibition of factor X.

It is about 72 kDa heavy and 444 amino acids large. It is produced by the liver.

Role in disease

Water et al. found deficiency of ZPI in 4.4% of a cohort of patients with thrombophilia (a tendency to thrombosis).

History

Han et al. first described ZPI in 1998. The same group further characterised it in 2000.

References

(October 2004). "Mutations within the protein Z-dependent protease inhibitor gene are associated with venous thromboembolic disease: a new form of thrombophilia". British Journal of Haematology.
(August 1998). "Isolation of a protein Z-dependent plasma protease inhibitor". Proceedings of the National Academy of Sciences of the United States of America.
(November 2000). "Characterization of the protein Z-dependent protease inhibitor". Blood.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

coagulation-system serine-protease-inhibitors

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