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Protein N-terminal methyltransferase

Field	Value
Name	Protein N-terminal methyltransferase
EC_number	2.1.1.244

Protein N-terminal methyltransferase (, NMT1 (gene), METTL11A (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-(protein) methyltransferase. This enzyme catalyses the following chemical reaction

:(1) 3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] \rightleftharpoons 3 S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein] (overall reaction) :(1a) S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] \rightleftharpoons S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,S)PK-[protein] :(1b) S-adenosyl-L-methionine + N-terminal-N-methyl-N-(A,S)PK-[protein] \rightleftharpoons S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-(A,S)PK-[protein] :(1c) S-adenosyl-L-methionine + N-terminal-N,N-dimethyl-N-(A,S)PK-serine-[protein] \rightleftharpoons S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein] :(2) 2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] \rightleftharpoons 2 S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein] (overall reaction) :(2a) S-adenosyl-L-methionine + N-terminal-PPK-[protein] \rightleftharpoons S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-PPK-[protein] :(2b) S-adenosyl-L-methionine + N-terminal-N-methyl-N-PPK-[protein] \rightleftharpoons S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein]

This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys.

References

(June 2010). "Identification of protein N-terminal methyltransferases in yeast and humans". Biochemistry.
(August 2010). "NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein". Nature.

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ec-2.1.1

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