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Prosultiamine

Chemical compound

Summary

Chemical compound

| Drugs.com =

| elimination_half-life =

Prosultiamine (INN; also known as thiamine propyl disulfide or TPD; brand name Jubedel,) is a disulfide thiamine derivative discovered in garlic in Japan in the 1950s, and is similar to allithiamine. It was developed as a treatment for vitamin B1 deficiency. It has improved lipid solubility relative to thiamine and is not rate-limited by dependency on intestinal transporters for absorption, hence the reasoning for its development.

Research

It has been studied as a potential treatment for infection with human T-lymphotropic virus (HTLV), since it has been shown to reduce viral load and symptoms.

References

References

  1. Swiss Pharmaceutical Society. (2000). "Index Nominum 2000: International Drug Directory (Book with CD-ROM)". Medpharm Scientific Publishers.
  2. (1997). "Dictionary of pharmacological agents". Chapman & Hall.
  3. (1954). ""allithiamine" A Newly Found Derivative of Vitamin B1". The Journal of Biochemistry.
  4. (April 1971). "Thiamine propyl disulfide: absorption and utilization". Annals of Internal Medicine.
  5. (August 1976). "Absorption, utilization and clinical effectiveness of allithiamines compared to water-soluble thiamines". Journal of Nutritional Science and Vitaminology.
  6. (15 August 2013). "Nervous System Disease: A New Outlet for an Old Drug?". Science Daily.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

formamides organic-disulfides aminopyrimidines thiamine
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