Propionibacterium

Pathology

Propionibacterium spp. are commensal bacteria that can occasionally cause infectious diseases. The most studied of these infections is acne vulgaris, caused by Cutibacterium acnes (formerly Propionibacterium acnes). It is a chronic inflammatory disease caused by the blockage of pilosebaceous units causing inflammatory lesions, non-inflammatory lesions or a mixture of both on the face, neck and/or chest. Acne vulgaris cannot be defined as an infectious disease since the bacteria is found on a vast majority of individuals without causing lesions. C. acnes colonize the skin only under certain favorable conditions. In most cases, C. acnes get trapped under the comedones where they proliferate to form micro-comedones, not visible to the naked eye, which can later form structures such as closed comedones (white heads) and open comedones. These comedones can rupture, releasing the follicular material inside the dermis. The cause of this rupture was thought to be the indirect effect of fat metabolism by the bacteria, however it was later found that bacteria are directly involved in comedome rupturing by producing factors such as proteases, hyaluronidases and neuraminidases which might be involved in thinning of the epithelium. C. acnes can also produce immune factors such as proinflammatory cytokine inducing-factors and chemotactic factors, and can induce host complement pathways.

Phylogeny

The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN) and National Center for Biotechnology Information (NCBI).

References

References

1. Orla-Jensen S.. (1909). "Die Hauptlinien des natürlichen Bakteriensystems". Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung II.
2. Cheung, Y.F., Fung, C., and Walsh, C. "Stereochemistry of propionyl-coenzyme A and pyruvate carboxylations catalyzed by transcarboxylase." 1975. ''Biochemistry'' 14(13), pg 2981.
3. Bojar, R., and Holland, K. "Acne and propionibacterium acnes." 2004. ''Clinics in Dermatology'' 22(5), pg. 375-379.
4. Rust, Susanne. (4 February 2012). "UC Berkeley Bacteria Study: Research Shows Humans A Major Source Of Germs". [[Huffington Post]].
5. (February 2017). "Nitrate Toxicity in Livestock". Oklahoma State University Extension Service.
6. Kiatpapan P., Murooka Y. Genetic manipulation system in propionibacteria. Journal of Bioscience and Bioengineering. 93 (1) (pp 1–8), 2002
7. [https://fankhauserblog.wordpress.com/2004/01/01/making-swiss-cheese/ Making Swiss Cheese - David B. Fankhauser, Ph.D.]
8. (2018-02-12). "Cutibacterium (Formerly Propionibacterium) avidum: A Rare but Avid Agent of Prosthetic Hip Infection". The Journal of Arthroplasty.
9. (2004). "PROPIONIBACTERIUM ACNES AND CHRONIC DISEASES". National Academies Press (US).
10. (2017-12-15). "Acne Vulgaris: Practice Essentials, Background, Pathophysiology".
11. "ACNE and ROSACEA {{!}} G. Plewig {{!}} Springer".
12. Noble, W. C.. (February 1984). "Skin microbiology: coming of age". Journal of Medical Microbiology.
13. (August 1995). "Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne.". Infection and Immunity.
14. (March 1977). "Chemoattractant properties of Corynebacterium parvum and pyran copolymer for human monocytes and neutrophils". Journal of the National Cancer Institute.
15. (November 1978). "Complement activation in acne vulgaris: in vitro studies with Propionibacterium acnes and Propionibacterium granulosum.". Infection and Immunity.
16. A.C. Parte. "Propionibacterium". [[List of Prokaryotic names with Standing in Nomenclature]] (LPSN).
17. C.L. Schoch. "Propionibacterium". [[National Center for Biotechnology Information]] (NCBI) taxonomy database.
18. "The LTP".
19. "LTP_all tree in newick format".
20. "LTP_10_2024 Release Notes".
21. "GTDB release 09-RS220".
22. "bac120_r220.sp_labels".
23. "Taxon History".