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Propiconazole

Propiconazole is a triazole fungicide, also known as a DMI, or demethylation inhibiting fungicide due to its binding with and inhibiting the 14-alpha demethylase enzyme from demethylating a precursor to ergosterol. Without this demethylation step, the ergosterols are not incorporated into the growing fungal cell membranes, and cellular growth is stopped.

Agriculture

Propiconazole is used agriculturally as a systemic fungicide on turfgrasses grown for seed and aesthetic or athletic value, wheat, mushrooms, corn, wild rice, peanuts, almonds, sorghum, oats, pecans, apricots, peaches, nectarines, plums, prunes and lemons. It is also used in combination with permethrin in formulations of wood preserver. Propiconazole is a mixture of four stereoisomers and was first developed in 1979 by Janssen Pharmaceutica. Propiconazole exhibits strong anti-feeding properties against the keratin-digesting Australian carpet beetle Anthrenocerus australis.

References

References

  1. ''Merck Index'', 11th Edition, '''7830'''.
  2. [https://pmep.cce.cornell.edu/profiles/extoxnet/metiram-propoxur/propiconazole-ext.html EXTOXNET]
  3. "See entry for Complete Wood Preservative".
  4. L. Toribio, M. J. del Nozal, J. L. Bernal, J. J. Jeménez und C. Alonso,'' J. Chromatography A'' 2004, ''1046'', 249-253.
  5. W. T. Thomson. 1997. Agricultural Chemicals. Book IV: Fungicides. 12th edition. Thomson Publications, Fresno, CA
  6. Sunderland, M. R.; Cruickshank, R. H.; Leighs, S. J. (2014). "The efficacy of antifungal azole and antiprotozoal compounds in protection of wool from keratin-digesting insect larvae". ''Textile Research Journal'' '''84''' (9): 924–931. http://trj.sagepub.com/content/84/9/924
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aromatase-inhibitors fungicides lanosterol-14α-demethylase-inhibitors triazoles
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