Pleomorphic lipoma

Signs and symptoms

Most cases of pleomorphic lipoma are seen in the subcutaneous tissue of the back, shoulder, and posterior neck. Less commonly, it can also happen in odd places like the tongue, vulva, palm, tonsillar fossa, orbit, and oral cavity. The lesion usually presents as a subcutaneous lump that is circumscribed, like the common lipoma.

Diagnosis

Histologically, bland spindle mesenchymal cells and mature fat make up the majority of the tissue in pleomorphic lipoma. Furthermore, multinucleated large cells with radically positioned nuclei in a "floret-like" pattern are strewn among the spindle cells. The histological spectrum is rather diverse, ranging from a tumor that primarily consists of spindle cells with only a few fat cells to a tumor that resembles an average lipoma with few spindle cells. Cytologically, multinucleated large cells feature irregular, hyperchromatic, and considerably unusual nuclei, while spindle cells have single elongated hyperchromatic nuclei and inconspicuous nucleoli. The two cell types' mitoses are uncommon. Collagen bands that resemble ropes are sporadically spaced throughout the cellular components and are typically a crucial diagnostic indicator for pleomorphic lipoma.

References

References

1. James, William; Berger, Timothy; Elston, Dirk (2005). ''Andrews' Diseases of the Skin: Clinical Dermatology''. (10th ed.). Saunders. {{ISBN. 0-7216-2921-0.
2. (1981). "Pleomorphic lipoma: a benign tumor simulating liposarcoma. A clinicopathologic analysis of 48 cases". Cancer.
3. (2002). "Pleomorphic lipoma of the tongue". Wiley.
4. (2002). "Intradermal spindle cell/pleomorphic lipoma of the vulva: case report and review of the literature". Wiley.
5. (1989). "[A pleomorphic lipoma of the palm--comparison to spindle cell lipoma]". Gan No Rinsho. Japan Journal of Cancer Clinics.
6. (2003). "Pleomorphic lipoma of the tonsillar fossa--a case report". Indian Journal of Pathology & Microbiology.
7. (2003). "Pleomorphic lipoma of the orbit: A case series and review of literature". Elsevier BV.
8. (2006). "Pleomorphic lipoma of the oral cavity. Report of a case". Minerva Stomatologica.
9. (2015). "Pleomorphic lipoma: A gentle giant of pathology". Medknow.
10. (2012-11-13). "Pleomorphic lipoma lacking mature fat component in extensive myxoid stroma: a great diagnostic challenge". Springer Science and Business Media LLC.