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Plague vaccine

Vaccine used against Yersinia pestis

Vaccine used against Yersinia pestis

| Drugs.com = Plague vaccine is a vaccine used against Yersinia pestis to prevent the plague. Inactivated bacterial vaccines have been used since 1890 but are less effective against the pneumonic plague, so live, attenuated vaccines and recombinant protein vaccines have been developed to prevent the disease. TOC

Plague immunization

The first plague vaccine was developed by bacteriologist Waldemar Haffkine in 1897. He tested the vaccine on himself to prove that the vaccine was safe. Later, Haffkine conducted a massive inoculation program in British India, and it is estimated that 26 million doses of Haffkine's anti-plague vaccine were sent out from Bombay between 1897 and 1925, reducing the plague mortality by 50%-85%.

A plague vaccine is used for an induction of active specific immunity in an organism susceptible to plague by means of administrating an antigenic material (a vaccine) via a variety of routes to people at risk of contracting any clinical form of plague. This method is known as plague immunization. There is strong evidence for the efficacy of administration of some plague vaccines in preventing or ameliorating the effects of a variety of clinical forms of infection by Yersinia pestis. Plague immunization also encompasses incurring a state of passive specific immunity to plague in a susceptible organism after administration of a plague serum or plague immunological in people with an immediate risk of developing the disease.

A systematic review by the Cochrane Collaboration found no studies of sufficient quality to be included in the review, and were thus unable to make any statement on the efficacy of modern plague vaccines.

References

References

  1. {{MeshName. Plague+Vaccine
  2. (September 2006). "Yersinia pestis CO92ΔyopH Is a Potent Live, Attenuated Plague Vaccine". Clin. Vaccine Immunol..
  3. "WALDEMAR MORDECAI HAFFKINE".
  4. Yang, Wei. (July 2010). "[The pioneer of cholera vaccine and plague vaccine-Haffkine]". Zhonghua Yi Shi Za Zhi (Beijing, China: 1980).
  5. (2020-12-11). "Waldemar Haffkine: The vaccine pioneer the world forgot". BBC News.
  6. Hawgood, Barbara J.. (February 2007). "Waldemar Mordecai Haffkine, CIE (1860-1930): prophylactic vaccination against cholera and bubonic plague in British India". Journal of Medical Biography.
  7. "WHO | Zoonotic Infections".
  8. (2000). "Vaccines for preventing plague". Cochrane Database Syst Rev.
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