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Pinc

Pregnancy-induced noncoding RNA

Field	Value
Name	Pregnancy induced noncoding RNA
Organism	mouse
TaxID	10090
Symbol	Pinc
EntrezGene	723792
RefSeqmRNA	NR_003202
Chromosome	1
EntrezChromosome	NC_000067.5
GenLoc_start	73437959
GenLoc_end	73454143

Pinc (pregnancy induced noncoding RNA) is a long non-coding RNA. It was originally identified in the mammary glands of oestrogen and progesterone-treated rats. Pinc may be a mammal-specific gene. It is conserved in a number of mammalian genomes (human, mouse, rat, chimpanzee, dog, cow and opossum), but not in fugu, zebrafish or xenopus genomes.

In mice, Pinc is expressed in the developing embryo and in the mammary glands of adults. Its expression in the mammary gland is induced by pregnancy and drops during lactation. It may have a role in cell survival and in the regulation of cell cycle progression.

References

(November 2001). "Persistent changes in gene expression induced by estrogen and progesterone in the rat mammary gland". Mol. Endocrinol..
(April 2006). "A noncoding RNA is a potential marker of cell fate during mammary gland development". Proc. Natl. Acad. Sci. U.S.A..

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non-coding-rna

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