Surf Wiki
Save to docs
general/steroids

From Surf Wiki (app.surf) — the open knowledge base

Physalin

Physalin

Physalins are steroidal constituents of Physalis plants which possess an unusual 13,14-seco-16,24-cyclo-steroidal ring skeleton (where the bond that is normally present between the 13 and 14 positions in other steroids is broken while a new bond between positions 16 and 24 is formed; see figure below). Since the isolation and the structure determination of Physalin A and Physalin B in 1969, more than a dozen Physalins were isolated from Physalis species, Physalis alkekengi, Physalis angulata, and Physalis lancifolia. These compounds have antimicrobial, and antiparasitic effects.

Chemical structures of Physalins A and B (left and middle respectively) and of the prototypical steroid ring skeleton (right) in which the atoms in the latter are numbered for reference. Ring bonds that differ between typical steroids and the physalins are represented by a wavy line (bond breaking) and a dashed line (bond forming).]]{{Clear}}

References

References

  1. (1970). "Structures of physalin A and physalin B, 13,14-seco-16,24-cyclo-steroids from Physalis alkekengi var. Francheti". J. Chem. Soc. Perkin Trans. 1.
  2. (2002). "Antimycobacterial physalins from Physalis angulata L. (Solanaceae)". Phytother Res.
  3. (2005). "Studies on antimicrobial activity, in vitro, of Physalis angulata L. (Solanaceae) fraction and physalin B bringing out the importance of assay determination". Mem. Inst. Oswaldo Cruz.
  4. (2005). "Antileishmanial physalins from Physalis minima". Chemistry & Biodiversity.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

steroids
Want to explore this topic further?

Ask Mako anything about Physalin — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report