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Phosphamidon

|Apamidon |Dimecron |Dixon |Famfos |Merkon |Sundaram 1975 6 mg/kg (mouse, IV) 20 mg/kg (rat, oral) 26 mg/kg (rat, subcut.) Phosphamidon is an organophosphate insecticide first reported in 1960. It acts as a cholinesterase inhibitor.

The commercial product typically exists as a mixture of 70% (Z)-isomer and 30% (E)-isomer.

Toxicity and regulation

Phosphamidon is very highly toxic to mammals and is listed as WHO Hazard Class Ia. International trade of phosphamidon is covered by the Rotterdam Convention.

References

References

  1. [http://www.inchem.org/documents/pds/pds/pest74_e.htm Data Sheet on Pesticides No. 74: Phosphamidon], [[International Programme on Chemical Safety]]
  2. Bachmann, Fritz. (1960). "Phosphamidon, a new phosphate ester with systemic action". Proc. Intern. Cong. Crop. Protection, 4th Congr., Hamburg.
  3. (1960). "Toxicology and pharmacology of a new systemic phosphoric acid ester insecticide phosphamidon (2-chloro-2-diethylcarbamoyl-1-methylvinyl dimethyl phosphate)". Archiv für Toxikologie.
  4. A harvester developed symptoms of moderately severe poisoning after working in a field that had been sprayed with the chemical 2 weeks earlier. He collapsed and exhibited significant depression of serum cholinesterase, but recovered completely within 2 days after successful treatment with atropine.S. Gitelson, J. T. Davidson, A. Werczberger. Phosphamidon poisoning. Br. J. Ind. Med. 22: 236-239, 1965.
Wikipedia Source

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acetylcholinesterase-inhibitors organophosphate-insecticides carboxamides organochlorides methyl-esters
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