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Phenylethylpyrrolidine

1-(2-Phenylethyl)pyrrolidine (PEP) is a chemical compound of the phenethylamine family. It is an analogue of 2-phenylethylamine where the amine has been replaced by a pyrrolidine ring.

Derivatives

The α-methyl (i.e., amphetamine derivative is 1-(α-methylphenethyl)pyrrolidine (MPEP), the β-keto derivative is phenacylpyrrolidine, and the combined α-methyl and β-keto (i.e., cathinone) derivative is α-pyrrolidinopropiophenone (α-PPP). Prolintane is the α-propyl derivative of PEP.

PEP is the base chemical structure for a series of stimulant drugs, including:

α-PBP
α-PHP
α-PPP
α-PVP
MDPBP
MDPPP
MDPV
MOPPP
MPBP
MPHP
MPPP
Naphyrone
Prolintane
Pyrovalerone
TH-PVP

All of these compounds differ from PEP in that the alpha carbon is extended and a ketone is attached to the beta carbon (with the exception of prolintane), among other modifications.

A cyclized phenethylamine and 2-aminoindane derivative is Pyr-AI ((2-indanyl)pyrrolidine). It is the analogue of 2-aminoindane (2-AI) in which the amine has been replaced with a pyrrolidine group. The drug has been described as having strong and long-lasting amphetamine-like effects in rodents.

References

(2014). "Bath salts, mephedrone, and methylenedioxypyrovalerone as emerging illicit drugs that will need targeted therapeutic intervention". Adv Pharmacol.
(2013). "Novel Psychoactive Substances". Elsevier.
(December 1973). "2-Aminoindans of pharmacological interest". J Med Chem.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

1-pyrrolidinyl-compounds phenylethylpyrrolidines stimulants

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