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Phenylalanine N-monooxygenase

Class of enzymes

Class of enzymes

FieldValue
NamePhenylalanine N-monooxygenase
EC_number1.14.14.40

Phenylalanine N-monooxygenase (, phenylalanine N-hydroxylase, CYP79A2) is an enzyme with systematic name L-phenylalanine,NADPH:oxygen oxidoreductase (N-hydroxylating). This enzyme catalyses the following chemical reaction

: L-phenylalanine + 2 O2 + 2 NADPH + 2 H+ \rightleftharpoons (E)-phenylacetaldoxime + 2 NADP+ + CO2 + 3 H2O (overall reaction) :(1a) L-phenylalanine + O2 + NADPH + H+ \rightleftharpoons N-hydroxy-L-phenylalanine + NADP+ + H2O: :(1b) N-hydroxy-L-phenylalanine + O2 + NADPH + H+ \rightleftharpoons N,N-dihydroxy-L-phenylalanine + NADP+ + H2O :(1c) N,N-dihydroxy-L-phenylalanine \rightleftharpoons (E)-phenylacetaldoxime + CO2 + H2O

Phenylalanine N-monooxygenase is a heme-thiolate protein (P-450). It is part of the pathway in plants which converts phenylalanine to the glucosinolate, glucotropaeolin, which contributes to the characteristic flavor of brassicas.

References

References

  1. (May 2000). "Cytochrome P450 CYP79A2 from Arabidopsis thaliana L. Catalyzes the conversion of L-phenylalanine to phenylacetaldoxime in the biosynthesis of benzylglucosinolate". The Journal of Biological Chemistry.
  2. (2020). "Glucosinolate structural diversity, identification, chemical synthesis and metabolism in plants". Phytochemistry.
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