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Pharmahuasca

Pharmaceutical version of the traditional Ayahuasca entheogen

Pharmaceutical version of the traditional Ayahuasca entheogen

Pharmahuasca is a pharmaceutical version of ayahuasca, a psychoactive decoction used by indigenous cultures in South America as part of traditional medicine and shamanism. Traditional ayahuasca is made by brewing the monoamine oxidase inhibitor (MAOI)-containing Banisteriopsis caapi vine with a dimethyltryptamine (DMT)-containing plant, such as Psychotria viridis. Pharmahuasca refers to a similar combination that uses a synthetically produced or pharmaceutical MAOI, such as moclobemide, instead of a plant.

Use and effects

DMT and harmaline or harmine are typically used as components of pharmahuasca. One study tested a formulation of 100 mg buccal harmine with 100 mg intranasal DMT, which produced an effect lasting 2 to 3hours. As a rule, the fewer the β-carbolines, the less nausea; the more DMT, the more spectacular the visions. The constituents are put into separate gelatin capsules. The capsules with harmaline/harmine are swallowed first and the capsules containing DMT are taken 15 to 20 minutes later. A synthetic MAOI can be used in place of harmaline and harmine, although caution must be taken when choosing an MAOI. The use of moclobemide, a reversible inhibitor of monoamine oxidase-A (RIMA), has been recorded and is safer than older irreversible MAOIs (such as isocarboxazid) due to its significantly shorter and more selective effects (although it still exhibits a wide range of dangerous drug-drug interactions).

Interactions

References

References

  1. (2024-12-28). "Pharmacokinetics and pharmacodynamics of an innovative psychedelic N,N-dimethyltryptamine/harmine formulation in healthy participants: a randomized controlled trial". The International Journal of Neuropsychopharmacology.
  2. Ott J. ''Ayahuasca Analogues: Pangaen Entheogens''. Natural Products Co.. 1994. '''34'''
  3. (2020-09-08). "Chemical Composition of Traditional and Analog Ayahuasca". Journal of Psychoactive Drugs.
  4. (2020-07-03). "The pharmacological interaction of compounds in ayahuasca: a systematic review". Brazilian Journal of Psychiatry.
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5-ht2a-agonists ayahuasca dimethyltryptamine entheogens monoamine-oxidase-inhibitors polysubstance-combinations psychedelic-drugs serotonin-receptor-agonists
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