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Perindopril/indapamide

Combination medication

Summary

Combination medication

Field	Value
verifiedrevid	464199158
type	combo
image	Perindopril and indapamide.svg
image_class	skin-invert-image
component1	Perindopril
class1	ACE inhibitor
component2	Indapamide
class2	Thiazide-like diuretic
tradename	Preterax, Noliprel, Coversyl Plus
pregnancy_AU
routes_of_administration	By mouth
ATC_prefix	C09
ATC_suffix	BA04
legal_AU	S4
legal_CA	Rx-only
legal_CA_comment
legal_UK
legal_US
legal_status	Rx-only
CAS_number	182176-83-6
PubChem	9940214
DrugBank_Ref
ChemSpiderID_Ref
ChemSpiderID	8115834

Perindopril/indapamide (marketed as Preterax, Coversyl Plus and Noliprel) is a combination medication which contains perindopril (an ACE inhibitor) and indapamide (a thiazide-like diuretic) both of which are used for the treatment of essential hypertension (high blood pressure).

Medical uses

High blood pressure

Administration

One tablet daily, preferably to be taken in the morning and before a meal.

Elderly: Normal dosage.

Kidney failure: Creatinine clearance (CrCl) 30 mL/min: no dosage modification. If CrCl

Contraindications

Absolute contraindications to taking perindopril/indapamide include a known allergy to perindopril, indapamide, or sulfonamides; history of Quincke's edema linked to previous ACE inhibitor therapy; end-stage kidney disease; serious liver disease; high levels of potassium in the blood; pregnancy; and lactation.

Relative contraindications to using this medication include combination therapy with lithium, potassium salts, potassium-sparing diuretics, and certain medicines which can cause abnormal heart rhythms.

Side effects

Side effects of perindopril/indapamide may include weakness, dizziness, headache, mood swings and/or sleep disturbances. Additionally, cramps, low blood pressure, allergic reactions, skin rashes, gastrointestinal disorders, dry cough, erectile dysfunctions, dry mouth, and a risk of dehydration in the elderly and in people who have congestive heart failure.

Immunosuppressed patients. Hemodialysis: risk of anaphylactoid reaction during hemodialysis with polyacrylonitrile membranes. Liver impairment.

Caution is recommended when prescribing perindopril/indapamide to people with electrolyte disorders, diabetes, gout, low blood pressure, or strict sodium-free diets, heart or kidney failure, atherosclerosis, renal artery stenosis, and in elderly people.

Pharmacology

Using a fixed combination of an ACE inhibitor and a chlorosulfamoyl diuretic leads to additive synergy of the antihypertensive effects of the two constituents. Its pharmacological properties are derived from those of each of the components taken separately, in addition to those due to the additive synergistic action of the two constituents, when combined, on vascular endothelium, arteriolocapillary microcirculation, and the target organs of hypertension.

Drug interactions

Not recommended: combinations with lithium, potassium-sparing diuretics, potassium (salts), antiarrhythmic drugs which can cause torsades de pointes, anesthetic drugs, cytostatics or immunosuppressive agents.

References

(7 July 2016). "Product monograph brand safety updates".
(26 November 2014). "ABC of Hypertension". Wiley.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

combination-antihypertensive-drugs laboratoires-servier

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