From Surf Wiki (app.surf) — the open knowledge base

Pepsin A

Field	Value
Name	Pepsin A
EC_number	3.4.23.1
CAS_number	9001-75-6
image	1pso.jpg
width	270
caption	Pepsin + inhibitor (l.blue), Human

Pepsin A (, pepsin, lactated pepsin, pepsin fortior, fundus-pepsin, elixir lactate of pepsin, P I, lactated pepsin elixir, P II, pepsin R, pepsin D) is an enzyme. This enzyme catalyses the following chemical reaction

: Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val, Gln4-His, Glu13-Ala, Ala14-Leu, Leu15-Tyr, Tyr16-Leu, Gly23-Phe, Phe24-Phe and Phe25-Tyr bonds in the B chain of insulin

The enzyme is a predominant endopeptidase in the gastric juice of vertebrates.

References

(September 1967). "Pepsinogen D. A fourth proteolytic zymogen from pig gastric mucosa". The Biochemical Journal.
(September 1967). "Pepsin D. A minor component of commercial pepsin preparations". The Biochemical Journal.
(1981). "Gastric proteinases--structure, function, evolution and mechanism of action". Essays in Biochemistry.
(1986). "Molecular structure of an aspartic proteinase zymogen, porcine pepsinogen, at 1.8 A resolution". Nature.
(1987). "New Comprehensive Biochemistry: Hydrolytic Enzymes". Elsevier.
(January 1987). "Evolution in the structure and function of aspartic proteases". Journal of Cellular Biochemistry.
(June 1988). "Secondary enzyme-substrate interactions: kinetic evidence for ionic interactions between substrate side chains and the pepsin active site". Biochemistry.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-3.4.23

Want to explore this topic further?

Ask Mako anything about Pepsin A — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report