Pentedrone

Pharmacology

Pentedrone acts as a norepinephrine-dopamine reuptake inhibitor (NDRI) without inducing monoamine release, a similar mechanism of action to methylphenidate. Its values for inhibition of monoamine reuptake have been reported to be 610nM for norepinephrine, 2,500μM for dopamine, and 135,000μM for serotonin. In rodents, pentedrone has been found to produce conditioned place preference (CPP), to be self-administered, and to dose-dependently stimulate locomotor activity. Hence, pentedrone shows psychostimulant-like and reinforcing effects in animals.

Side effects

Pentedrone has been linked to at least one death where it was combined with α-PVP and caused heart failure.

Detection

A forensic standard of pentedrone is available, and the compound has been posted on the Forendex website of potential drugs of abuse.

Legal status

On January 28, 2014, the DEA listed it, along with nine other synthetic cathinones, on the Schedule 1 with a temporary ban, effective February 27, 2014.

Pentedrone is an Anlage II controlled drug in Germany.

As of October 2015 Pentedrone is a controlled substance in China.

Pentedrone is banned in the Czech Republic.

Pentedrone is banned in the Slovak Republic.

References

References

1. Anvisa. (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial". [[Diário Oficial da União]].
2. "Substance Details Pentedrone".
3. "EMCDDA Annual Report 2010".
4. [http://www.drugs.ie/features/feature/research_on_head_shop_drugs_in_dublin_part_2 Research on Head Shop drugs in Dublin: Part 2]
5. [http://www.dit.ie/cser/media/ditcser/documents/Head_Report2011_overview.pdf An overview of new psychoactive substances and the outlets supplying them]
6. (April 2012). "Mass, NMR and IR spectroscopic characterization of pentedrone and pentylone and identification of their isocathinone by-products". Forensic Science International.
7. (January 2012). "Chemical analysis of two new designer drugs: buphedrone and pentedrone". Drug Testing and Analysis.
8. (January 2015). "Analysis of the first- and second-generation Raving Dragon Novelty Bath Salts containing methylone and pentedrone". Journal of Forensic Sciences.
9. (November 2014). "Analytical profiles of "legal highs" containing cathinones available in the area of Lisbon, Portugal". Forensic Science International.
10. (April 2014). "Monoamine transporter and receptor interaction profiles of a new series of designer cathinones". Neuropharmacology.
11. (January 2017). "The new stimulant designer compound pentedrone exhibits rewarding properties and affects dopaminergic activity". Addiction Biology.
12. (May 2015). "A Fatal Case of Pentedrone and α-Pyrrolidinovalerophenone Poisoning". Journal of Analytical Toxicology.
13. "Pentedrone". Southern Association of Forensic Scientists.
14. (28 January 2014). "Temporary Placement of 10 Synthetic Cathinones into Schedule I".
15. (27 September 2015). "关于印发《非药用类麻醉药品和精神药品列管办法》的通知". China Food and Drug Administration.
16. "Látky, o které byl doplněn seznam č. 4 psychotropních látek (příloha č. 4 k nařízení vlády č. 463/2013 Sb.)". Ministerstvo zdravotnictví.
17. "Zoznam omamných látok a psychotropných látok zaradených do I., II. A III. skupiny (ochrana pred omamnými látkami) {{!}} Lewik".