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Pecilocin

Pecilocin (brand name Variotin) is a pyrrolidine anti-fungal. It is produced by Paecilomyces varioti Bainer var. antibioticus and was first isolated by Setsuo Takeuchi in 1959. Later, it was established that other fungi also produce this compound, which include Aspergillus candidus and Aspergillus montenegroi.

Uses

Pecilocin is indicated for topical treatment of fungal infections of skin and its adnexa, i.e.:

  • skin mycoses (including tinea versicolor)
  • onchomycosis
  • scalp infections (e.g. tinea capitis)

Antifungal spectrum

Pecilocin is a fungistatic and has activity against genera Blastomyces, Cryptococcus, Epidermophyton, Microsporum and Trichophyton (with MIC less or equal to 0,25 μg/ml). C. albicans is inherently resistant.

Adverse effects

Common adverse effects associated with pecilocin include: skin irritation (observed in 2-6.5% of patients), as well as contact dermatitis. Some patients might exhibit allergy to pecilocin.

Biosynthesis

A radioactive carbon study of pecilocin biosynthetic pathway conducted by Nobuo Tanaka showed it is synthesised from acetic acid, glutamate and L-methionine.

References

References

  1. "Pecilocin {{!}} C17H25NO3 {{!}} ChemSpider".
  2. (September 1959). "Studies on variotin, a new antifungal antibiotic. I. Preparations and properties of variotin". The Journal of Antibiotics.
  3. (2021-12-23). "Biocontrol Potential of ''Aspergillus'' Species Producing Antimicrobial Metabolites". Frontiers in Microbiology.
  4. (2019). "Leki współczesnej terapii". Medical Tribune Polska.
  5. (1967). "Biosynthesis". Springer Berlin Heidelberg.
  6. (2016). "Meyler's Side Effects of Drugs". Elsevier.
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