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Paromamine 6'-oxidase

Class of enzymes


Summary

Class of enzymes

FieldValue
NameParomamine 6'-oxidase
EC_number1.1.3.43

Paromamine 6'-oxidase (, btrQ (gene), neoG (gene), kanI (gene), tacB (gene)) is an enzyme with systematic name paromamine:oxygen 6'-oxidoreductase. This enzyme catalyses the following chemical reaction

: paromamine + O2 \rightleftharpoons 6'-dehydroparomamine + H2O2

This enzymes participates in biosynthesis of several aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin.

References

References

  1. (February 2007). "Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin". ChemBioChem.
  2. (February 2008). "Biosynthesis of 3'-deoxy-carbamoylkanamycin C in a Streptomyces tenebrarius mutant strain by tacB gene disruption". The Journal of Antibiotics.
  3. (September 2011). "The oxidoreductases LivQ and NeoQ are responsible for the different 6'-modifications in the aminoglycosides lividomycin and neomycin". Journal of Applied Microbiology.
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