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Palmoplantar hyperhidrosis

Excessive sweating localized to the hands and feet

Summary

Excessive sweating localized to the hands and feet

Field	Value
image	Hyper schweisshand sb.jpg
caption	Hyperhidrosis seen on the hands.
specialty	Dermatology

Palmoplantar hyperhidrosis is excessive sweating localized to the palms of the hands and soles of the feet. It is a form of focal hyperhidrosis in that the excessive sweating is limited to a specific region of the body. As with other types of focal hyperhidrosis (e.g. axillary and craniofacial) the sweating tends to worsen during warm weather.

Signs and symptoms

Palmoplantar hyperhidrosis is a frequent disorder when excessive amounts of sweat are inappropriately secreted by the eccrine glands in the palms and soles.

Causes

There is little knowledge about the pathogenesis of focal hyperhidrosis. Focal hyperhidrosis may indicate a complicated autonomic nervous system malfunction involving both parasympathetic and sympathetic pathways. Given that 30% to 50% of patients have a family history of hyperhidrosis, there may be a genetic susceptibility.

Diagnosis

Because the excessive sweating is easily noticeable, palmoplantar hyperhidrosis is a clinical diagnosis.

Treatment

For palmoplantar hyperhidrosis, 20% aluminum chloride hexahydrate in absolute anhydrous ethyl alcohol (Drysol) is the most effective topical treatment. Other topical treatments such as potassium permanganate, tannic acid (2 to 5 percent solutions), resorcinol, boric acid, formaldehyde, methenamine, and glutaraldehyde have yielded less than desirable results.

Iontophoresis is a well-known treatment for hyperhidrosis that involves applying a direct electrical current to the skin. Iontophoresis has been combined with a variety of substances, such as tap water, salt water, and anticholinergic medications.

Botulinum toxin type A (Botox) injections are safe, efficient, and frequently enhance the quality of life for those who suffer from hyperhidrosis. The toxin damages the sweat glands' post-ganglionic sympathetic innervation and prevents acetylcholine from being released at the neuromuscular junction.

References

James, William; Berger, Timothy; Elston, Dirk (2005). ''Andrews' Diseases of the Skin: Clinical Dermatology''. (10th ed.). Saunders. {{ISBN. 0-7216-2921-0.
(2004-03-01). "Palmoplantar Hyperhidrosis: A Therapeutic Challenge". American Family Physician.
Haider, A.. (2005-01-04). "Focal hyperhidrosis: diagnosis and management". Canadian Medical Association Journal.
Stolman, Lewis P.. (1998). "Treatment of Hyperhidrosis". Elsevier BV.
(1952). "The treatment of hyperhidrosis of hands and feet with constant current". American Journal of Physical Medicine.
(1993-11-01). "Generation and transit pathway of H+ is critical for inhibition of palmar sweating by iontophoresis in water". American Physiological Society.
(2002). "Long-Term Efficacy and Quality of Life in the Treatment of Focal Hyperhidrosis with Botulinum Toxin A". Ovid Technologies (Wolters Kluwer Health).
(1998). "Botulinum toxin therapy for palmar hyperhidrosis". Elsevier BV.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

conditions-of-the-skin-appendages

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