From Surf Wiki (app.surf) — the open knowledge base

Pain wind-up

Perception of pain

Pain wind-up is the increase in pain intensity over time when a given stimulus is delivered repeatedly above a critical rate. It is caused by repeated stimulation of group C peripheral nerve fibers, leading to progressively increasing electrical response in the corresponding spinal cord (posterior horn) neurons due to priming of the NMDA receptor based response. It describes an exponentially progressive increase in firing of wide dynamic range neuron with repeated stimulation.

References

(29 May 2011). "Introduction to Skin Biothermomechanics and Thermal Pain". Springer.
Pitcher and Henry (2000). ''Eur. J. Neurosci.'', 12:2006–2020.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

pain

Want to explore this topic further?

Ask Mako anything about Pain wind-up — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report