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P57 (glycoside)

P57AS3

P57 is an oxypregnane steroidal glycoside isolated from the traditional African medicine Hoodia gordonii. P57 is hypothesized to be the chemical constituent responsible for the putative appetite suppressant activity of Hoodia.

In a study on rats at Brown Medical School, intracerebroventricular injections of the purified P57 demonstrated that the compound has a likely central nervous system (CNS) mechanism of action like that of neuroactive steroids. The studies demonstrated that the compound increases the content of ATP by 50-150% in hypothalamic neurons. In addition, third ventricle administration of P57 reduced subsequent 24-hour food intake by 40-60%.

References

References

  1. (Oct 2007). "An appetite suppressant from Hoodia species". Phytochemistry.
  2. van Heerden FR. (Oct 2008). "Hoodia gordonii: a natural appetite suppressant". Journal of Ethnopharmacology.
  3. Avula, Bharathi. (May–June 2006). "Determination of the appetite suppressant P57 in Hoodia gordonii plant extracts and dietary supplements by liquid chromatography/electrospray ionization mass spectrometry (LC-MSD-TOF) and LC-UV methods". Journal of AOAC International.
  4. MacLean, David B.. (September 2004). "Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside". Brain Research.
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anorectics steroidal-glycosides
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