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Ovariectomized rat
An ovariectomized rodent (OVX) is a female rat or mouse whose ovaries have been removed. Currently, there is no single animal model that precisely replicates the stages of osteoporosis in humans,{{cite journal
Of these animal models, the ovariectomised rat model remains the most popular choice as it has been validated to represent the most important clinical features of estrogen deficiency-induced (or postmenopausal) bone loss in the adult human,{{cite book
It also offers certain advantages compared the other animal models like rabbits and sheep. These include the ability to use peripheral micro-computed tomography (pQmicro-CT) in in vivo micro-CT to perform in vivo analyses,{{cite journal
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