Oscar Hertwig

Biography

Hertwig was the elder brother of zoologist-professor Richard Hertwig (1850–1937). The Hertwig brothers were the most eminent scholars of Ernst Haeckel (and Carl Gegenbaur) from the University of Jena. They were independent of Haeckel's philosophical speculations but took his ideas in a positive way to widen their concepts in zoology. Initially, between 1879 and 1883, they performed embryological studies, especially on the theory of the coelom (1881), the fluid-filled body cavity. These problems were based on the phylogenetic theorems of Haeckel, i.e. the biogenic theory (German = biogenetisches Grundgesetz), and the "gastraea theory".

Within 10 years, the two brothers moved apart to the north and south of Germany. Oscar Hertwig later became a professor of anatomy in 1888 in Berlin; however, Richard Hertwig had moved 3 years prior, becoming a professor of zoology in Munich from 1885 to 1925, at Ludwig Maximilian University, where he served the last 40 years of his 50-year career as a professor at 4 universities.

Hertwig was a leader in the field of comparative and causal animal-developmental history. He also wrote a leading textbook. By studying sea urchins he proved that fertilization occurs due to the fusion of a sperm and egg cell. He recognized the role of the cell nucleus during inheritance and chromosome reduction during meiosis: in 1876, he published his findings that fertilization includes the penetration of a spermatozoon into an egg cell. Hermann Fol also observed this in the same year. Hertwig's experiments with frog eggs revealed the 'long axis rule', or Hertwig rule. According to this rule, cell divides along its long axis.

In 1885 Hertwig wrote that nuclein (later called nucleic acid) is the substance responsible not only for fertilization but also for the transmission of hereditary characteristics. This early suggestion was proven correct much later in 1944 by the Avery–MacLeod–McCarty experiment which showed that this is indeed the role of the nucleic acid DNA.

While Hertwig was interested in developmental biology and evolution, he was opposed to chance as assumed in Charles Darwin´s theory. His most important theoretical book was: "Das Werden der Organismen, eine Widerlegung der Darwinschen Zufallslehre" (Jena, 1916) (translation: "The Origin of Organisms – a Refutation of Darwin's Theory of Chance").

Hertwig was elected a member of the Royal Swedish Academy of Sciences in 1903.

In 1905, Hertwig was named an honorary member of the American Association for Anatomy.

Hertwig is known as Oscar Hedwig in the book "Who discovered what when" by David Ellyard. A history of the discovery of fertilization for mammals including scientists like Hertwig and other workers is given by the book "The Mammalian Egg" by Austin.

Works

• Die Elemente der Entwicklungslehre des Menschen und der Wirbeltiere : Anleitung und Repetitorium für Studierende und Ärzte. Fischer, Jena 5th ed. 1915 Digital edition by the University and State Library Düsseldorf
• Das Problem der Befruchtung und der Isotropie des Eies. Eine Theorie der Vererbung. Jenaische Zeitschrift fur Naturwissenschaft 18, 276–318.

References

Other sources

• {{Citation |publication-date=Apr 2, 1990
• {{Citation |publication-date=Jun 1980
• {{Citation
• {{Citation |publication-date=1970
• Cremer, T. 1985. Von der Zellenlehre zur Chromosomentheorie. Springer Vlg., Heidelberg. This German book can be downloaded here http://www.t-cremer.de/main_de/cremer/personen/info_T_Cremer.htm#book.
• Krafft, F., and A. Meyer-Abich (ed.). 1970. Große Naturwissenschaftler – Biographisches Lexikon. Fischer Bücherei GmbH, Frankfurt a. M. & Hamburg.
• Mol. Cell. Biol.-lecture, Heidelberg, D.-H. Lankenau. Early to recent key-discoveries: From Germline Theory to Modern Gene Modification.
• Weindling, Paul. 1991. Darwinism and Social Darwinism in Imperial Germany: The Contribution of the Cell Biologist Oscar Hertwig (1849–1922). Forschungen zur Medizin- und Biologiegeschichte vol. 3, (Stuttgart: G. Fischer in association with Akademie der Wissenschaften und der Literatur Mainz, 1991).

References

1. [https://www.bbvaopenmind.com/en/science/leading-figures/oscar-hertwig-the-first-man-to-observe-sexual-reproduction/ "Oscar Hertwig, the First Man to Observe Sexual Reproduction"]. Retrieved 12 February 2021.
2. Clift D, Schuh M. (2013). "Restarting life: fertilization and the transition from meiosis to mitosis (Box 1)". [[Nature Reviews Molecular Cell Biology]].
3. (2012). "An amazing 10 years: the discovery of egg and sperm in the 17th century". Reprod Domest Anim.
4. (1884). "Das Problem der Befruchtung und der Isotropie des Eies: eine Theorie der Vererbung". Fischer.
5. Gribbin, John. (2002). "The Scientists: A History of Science Told Through the Lives of Its Greatest Inventors". Random House.
6. (1987). "The American Association of Anatomists, 1888-1987: essays on the history of anatomy in America and a report on the membership--past and present". Williams & Wilkins.
7. (2017). "Who discovered what when? : five hundred years of great scientific discoveries". New Holland.
8. (1961). "The Mammalian Egg". Springfield, Ill., Thomas.