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Organification

Organification is a biochemical process that takes place in the thyroid gland. It is the incorporation of iodine into thyroglobulin for the production of thyroid hormone, a step done after the oxidation of iodide by the enzyme thyroid peroxidase (TPO) Since iodine is an inorganic compound, and is being attached to thyroglobulin, a protein, the process is termed as "organification of iodine".

Thionamides can block organification.

References

References

  1. (May 2007). "Comprehensive Pharmacy Review". Lippincott Williams and Wilkins.
  2. "Endocrine Physiology". McGraw Hill Professional.
  3. (January 2016). "Meyler's Side Effects of Drugs". Elsevier.
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