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Open-label trial

Clinical trial where the treatment isn't hidden

Summary

Clinical trial where the treatment isn't hidden

An open-label trial, or open trial, is a type of clinical trial in which information is not withheld from trial participants.{{cite web

Open-label trials may be appropriate for comparing two similar treatments to determine which is most effective, such as a comparison of different prescription anticoagulants, or possible relief from symptoms of some disorders when a placebo is given.

An open-label trial may still be randomized. Open-label trials may also be uncontrolled (without a placebo group), with all participants receiving the same treatment.

References

References

  1. (2020). "Double-blind (trial)". Merriam-Webster Medical Dictionary.
  2. (2020). "Double-blind study". HIV.gov, Office of AIDS Research, US National Institutes of Health.
  3. (2011). "External and internal validity of open label or double-blind trials in oral anticoagulation: better, worse or just different?". Journal of Thrombosis and Haemostasis.
  4. (25 May 2017). "Open-label versus double-blind placebo treatment in irritable bowel syndrome: study protocol for a randomized controlled trial". Trials.
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This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

design-of-experiments clinical-trials scientific-method research-methods
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