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Olsalazine

Pharmaceutical drug used for ulcerative colitis

Pharmaceutical drug used for ulcerative colitis

| Drugs.com =

| elimination_half-life = 0.9 hours

Olsalazine is an anti-inflammatory medication used in the treatment of ulcerative colitis. It is sold under the brand name Dipentum.

Olsalazine itself is a prodrug of mesalazine (5-aminosalicyclic acid or 5-ASA) and is not absorbed in the small intestine. Instead it continues through to the colon where it is cleaved into two molecules of 5-ASA by azoreductases produced by colonic bacteria. Olsalazine thus exerts its anti-inflammatory effect by its colonic breakdown into 5-ASA which inhibits cyclooxygenase and lipoxygenase thereby reducing prostaglandin and leukotriene production.

History

Olsalazine gained Food and Drug Administration (FDA) approval in 1990.

Supply

The drug is supplied by UCB Pharma.

Research

In 2006 the Australian biotech company Giaconda received a European patent for a combination therapy for treating constipation-predominant irritable bowel syndrome that uses olsalazine and the anti-gout drug colchicine, for trials the following year.

References

References

  1. (6 September 2019). "Olsalazine (Dipentum) Use During Pregnancy".
  2. (July 1990). "Olsalazine--a further choice in ulcerative colitis". Drug and Therapeutics Bulletin.
  3. (April 1991). "Olsalazine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in inflammatory bowel disease". Drugs.
  4. "Olsalazine Sodium 250 mg Capsules - Summary of Product Characteristics (SmPC) - (emc)".
  5. (28 December 2006). "Giaconda gets European patent for drug". The Sydney Morning Herald.
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