Nuclear receptor coactivator 1

Interactions

Nuclear receptor coactivator 1 possesses a basic helix-loop-helix (bHLH) domain and has been shown to interact with:

• Androgen receptor,

• C-Fos,

• C-jun,

• CIITA,

• CREB-binding protein,

• Cyclin D1,

• Estrogen receptor alpha,

• Glucocorticoid receptor,

• NFKB1,

• PCAF,

• PPARGC1A,

• Peroxisome proliferator-activated receptor alpha,

• SNW1,

• STAT3,

• STAT6,

• TRIP4, and

• Thyroid hormone receptor beta.

References

References

1. (1995). "Sequence and characterization of a coactivator for the steroid hormone receptor superfamily". Science.
2. (1998). "The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors". Journal of Biological Chemistry.
3. (4 October 2023). "''NCOA1'' Gene - Nuclear Receptor Coactivator 1".
4. (Oct 2004). "Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells". Molecular Endocrinology.
5. (Oct 2002). "Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells". Journal of Biological Chemistry.
6. (Dec 1999). "The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1". Molecular and Cellular Biology.
7. (Jun 2000). "Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Molecular Endocrinology.
8. (Jul 1998). "Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits". Journal of Biological Chemistry.
9. (Nov 1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". Journal of Biological Chemistry.
10. (Dec 2003). "Steroid receptor coactivator 1 links the steroid and interferon gamma response pathways". Molecular Endocrinology.
11. (Jan 2001). "Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1". Molecular and Cellular Biology.
12. (May 2002). "Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase". Molecular and Cellular Biology.
13. (Nov 1998). "Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1". Genes & Development.
14. (Oct 2000). "BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation". Molecular and Cellular Biology.
15. (Jan 1998). "Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor". EMBO Journal.
16. (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proceedings of the National Academy of Sciences, USA.
17. (Apr 2001). "Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140". Molecular Endocrinology.
18. (Jul 2002). "A point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid receptor coactivator 1". Journal of Biological Chemistry.
19. (Sep 1997). "Steroid receptor coactivator-1 is a histone acetyltransferase". Nature.
20. (Nov 1999). "Activation of PPARgamma coactivator-1 through transcription factor docking". Science.
21. (Dec 1997). "p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha". Journal of Biological Chemistry.
22. (Jun 1998). "A regulatory role for RIP140 in nuclear receptor activation". Molecular Endocrinology.
23. (Nov 2001). "Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription". Journal of Biological Chemistry.
24. (Mar 2002). "Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a". Journal of Biological Chemistry.
25. (Dec 2001). "Transcriptional activation by STAT6 requires the direct interaction with NCoA-1". Journal of Biological Chemistry.
26. (Sep 2002). "An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1". Journal of Biological Chemistry.
27. (Sep 1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Molecular and Cellular Biology.
28. (Oct 1998). "Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors". Endocrinology.
29. (Jun 1997). "Analysis of the functional role of steroid receptor coactivator-1 in ligand-induced transactivation by thyroid hormone receptor". Molecular Endocrinology.