Nuclear receptor co-repressor 1

Family

It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is Nuclear receptor co-repressor 2.

Interactions

Nuclear receptor co-repressor 1 has been shown to interact with:

• Androgen receptor,
• CHD1,
• Calcitriol receptor
• GPS2,
• Glucocorticoid receptor,
• HDAC3,
• HDAC4,
• HDAC7A,
• HDAC9,
• HEY2,
• Histone deacetylase 5,
• MAP3K7IP2,
• MECP2,
• Peroxisome proliferator-activated receptor alpha,
• Peroxisome proliferator-activated receptor gamma
• Promyelocytic leukemia protein,
• RUNX1T1,
• Retinoic acid receptor alpha,
• Retinoic acid receptor gamma,
• SAP30,
• TBL1XR1,
• TBL1X, and
• ZBTB33.

References

References

1. (October 1995). "Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor". Nature.
2. (September 1998). "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex". Proc. Natl. Acad. Sci. U.S.A..
3. (1998). "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex". Proc Natl Acad Sci USA.
4. (2011). "NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function". Cell.
5. UniProt [https://www.uniprot.org/uniprot/?query=family:%22N-CoR+nuclear+receptor+corepressors+family%22 Nuclear receptor corepressors family] Page accessed June 26, 2016
6. (October 2004). "Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells". Mol. Endocrinol..
7. (January 2004). "Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor". Mol. Endocrinol..
8. (July 2002). "Inhibition of the dihydrotestosterone-activated androgen receptor by nuclear receptor corepressor". Mol. Endocrinol..
9. (February 2005). "The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists". J. Biol. Chem..
10. (August 2003). "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins". Biochem. Biophys. Res. Commun..
11. (December 2002). "AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor". Cancer Res..
12. (December 1998). "The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators". Biochem. Biophys. Res. Commun..
13. (May 2003). "Dissociation of steroid receptor coactivator 1 and nuclear receptor corepressor recruitment to the human glucocorticoid receptor by modification of the ligand-receptor interface: the role of tyrosine 735". Mol. Endocrinol..
14. (July 2002). "RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding". J. Biol. Chem..
15. (January 2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Mol. Cell.
16. (December 2000). "A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1". J. Biol. Chem..
17. (September 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". J. Biol. Chem..
18. (May 2003). "The histone deacetylase 9 gene encodes multiple protein isoforms". J. Biol. Chem..
19. (September 2001). "HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling". Mol. Cell. Biol..
20. (March 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Mol. Cell.
21. (January 2000). "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway". Genes Dev..
22. (July 2002). "Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein". Cell.
23. (September 2001). "The Ski protein family is required for MeCP2-mediated transcriptional repression". J. Biol. Chem..
24. (May 1999). "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein". J. Biol. Chem..
25. (June 2001). "Role of PML and PML-RARalpha in Mad-mediated transcriptional repression". Mol. Cell.
26. (October 2001). "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain". Mol. Cell. Biol..
27. (January 2001). "Oligomerization of ETO is obligatory for corepressor interaction". Mol. Cell. Biol..
28. (April 1998). "Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia". Blood.
29. (July 1998). "SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors". Mol. Cell.
30. (March 2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J..
31. (May 2000). "A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness". Genes Dev..