Surf Wiki
Save to docs
general/opioids

From Surf Wiki (app.surf) — the open knowledge base

Nortilidine

Chemical compound

Chemical compound

| elimination_half-life =

Nortilidine is the major active metabolite of tilidine. It is formed from tilidine by demethylation in the liver. The racemate has opioid analgesic effects roughly equivalent in potency to that of morphine. The (1R,2S)-isomer has NMDA antagonist activity. The drug also acts as a dopamine reuptake inhibitor. The reversed-ester of nortilidine is also known, as is the corresponding analogue with the cyclohexene ring replaced by cyclopentane, which have almost identical properties to nortilidine.

Use

Nortilidine has been sold as a designer drug, first being identified in Poland in May 2020.

References

References

  1. "Process for Substituted Cyclohexenes its Products".
  2. (November 2002). "Sequential first-pass metabolism of nortilidine: the active metabolite of the synthetic opioid drug tilidine". Journal of Clinical Pharmacology.
  3. (February 2015). "Novel psychoactive substances of interest for psychiatry". World Psychiatry.
  4. "Cycloaromatic compounds, analgesic Properties thereof and Method of use thereof as analgesic".
  5. Personal Communication with Derek P. Reynolds
  6. (10 August 2020). "EU Early Warning System Situation Report. Situation report 2". European Monitoring Centre for Drugs and Drug Addiction (EMCDDA).
  7. (2020). "Identifying New/Emerging Psychoactive Substances at the Time of COVID-19; A Web-Based Approach". Frontiers in Psychiatry.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

opioids dopamine-reuptake-inhibitors nmda-receptor-antagonists cyclohexenes
Want to explore this topic further?

Ask Mako anything about Nortilidine — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report