NME1

Function

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally occurring transcripts (NME1-NME2), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.

A bioinformatics study published in 2023 suggested that the NME1 gene might have a prognostic role in neuroblastoma.

Interactions

NME1 has been shown to interact with:

• Aurora A kinase,
• CD29
• NME3,
• Protein SET,
• RAR-related orphan receptor alpha,
• RAR-related orphan receptor beta, and
• TERF1.

References

References

1. (February 1994). "Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1". Hum. Genet..
2. "Entrez Gene: NME1 non-metastatic cells 1, protein (NM23A) expressed in".
3. (4 March 2023). "Signature literature review reveals ''AHCY'', ''DPYSL3'', and ''NME1'' as the most recurrent prognostic genes for neuroblastoma". BioData Mining.
4. (December 2002). "The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1". Nucleic Acids Res..
5. (June 2002). "Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement". J. Biol. Chem..
6. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature.
7. (September 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death Differ..
8. (March 2003). "SET-ting the stage for life and death". Cell.
9. (October 1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun..
10. (February 1998). "Association of nucleoside diphosphate kinase nm23-H2 with human telomeres". Biochem. Biophys. Res. Commun..