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Niridazole

Chemical compound

Summary

Chemical compound

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Niridazole is a schistosomicide. It is used to treat schistosomiasis, the helmintic disease caused by certain flatworms (trematodes) from the genus Schistosoma (formerly Bilharzia). It is also known by its trade name Ambilhar. It is usually given as tablets.

Niridazole has central nervous system toxicity and can cause dangerous side effects, such as hallucinations. Also, it may cause allergic reactions in sensitive people. However, it is one of the most effective schistosomicide drugs.

It has recently also been investigated for use in the treatment of periodontitis. TOC

Mechanism of action

Niridazole is rapidly concentrated in the parasite and inhibits oogenesis and spermatogenesis. The compound also inhibits the phosphofructokinase enzyme, leading to glycogen depletion and hepatic shift.

References

References

  1. (September 1983). "Reductive metabolism of niridazole by adult Schistosoma mansoni. Correlation with covalent drug binding to parasite macromolecules". Molecular Pharmacology.
  2. [https://www.nlm.nih.gov/toxnet/index.html Toxicology Data Network – Niridazole]
  3. (November 1975). "Clinical evaluation of niridazole and hycanthone in schistosomiasis mansoni endemic areas". Journal of Toxicology and Environmental Health.
  4. (November 2007). "Ethylcellulose inserts of an orphan drug for periodontitis: preparation, in vitro, and clinical studies". Drug Delivery.
  5. (2006). "Niridazole biodegradable inserts for local long-term treatment of periodontitis: possible new life for an orphan drug". Drug Delivery.
Wikipedia Source

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antiparasitic-agents iarc-group-2b-carcinogens imidazolidinones nitrothiazoles
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