Surf Wiki
Save to docs
general/3-pyridyl-compounds

From Surf Wiki (app.surf) — the open knowledge base

Nicotinyl alcohol

Chemical compound

Chemical compound

| Drugs.com = | elimination_half-life =

Nicotinyl alcohol (pyridylcarbinol) is a niacin derivative used as a hypolipidemic agent and as a vasodilator. It causes flushing and may decrease blood pressure.

It appears as a crystal that dissolves in water and alcohol with ease, also soluble in ether; melting range 147–148 °C.

Nicotinic acid is a brief peripheral vasodilator; this compound was made to make its action longer and effective. It provokes cutaneous flushing in head and upper thorax with heat, but with no major effects in blood pressure. It is used in peripheral vascular diseases, like arteriosclerosis obliterans, Raynaud's disease, thromboangiitis obliterans (Buerger's disease), arterial embolism, chilblains or migraine associated with vascular spasm.

Fischer and Tebrock worked with this drug in more than two hundred patients for more than three years, achieving effective improvements, mainly in symptoms related to intermittent claudication, ulcer healing and others.

Derivatives

At least a couple of uses for this agent were discovered over the years:

  1. Eniclobrate
  2. Mepiroxol
  3. Nicofibrate
  4. Pantenicate (Topanicate, MG 28362)

References

References

  1. Norwood WF. (1963). "Vasodilator Effects of Nicotinyl Tartrate (Roniacol Tartrate)". [[JAMA (journal).
  2. (2012). "Ronicol Retard". Medical Dictionary Online.
  3. (1951). "An evaluation of roniacol tartrate in arteriosclerosis obliterans". New York State Journal of Medicine.
  4. "Medical Dictionary, Dictionary of medicine and human biology, medical, biological and chemical terminology".
  5. (July 7, 2011). "Buergers disease by dr .ravinder narwal".
  6. (1957). "Nicotinyl Alcohol Tartrate in Intermittent Claudication". British Medical Journal.
  7. (1953). "Nicotinic alcohol (roniacol) in peripheral vascular diseases and allied conditions: its use and limitations". New York State Journal of Medicine.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

3-pyridyl-compounds hydroxymethyl-compounds lipid-lowering-agents vasodilators
Want to explore this topic further?

Ask Mako anything about Nicotinyl alcohol — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report