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Neuropeptide B/W receptor

G-protein coupled receptor

Field	Value
Name	neuropeptides B/W receptor 1
HGNCid	4522
Symbol	NPBWR1
AltSymbols	GPR7
EntrezGene	2831
OMIM	600730
RefSeq	NM_005285
UniProt	P48145
Chromosome	8
Arm	p22
Band	-q21.13

The neuropeptide B/W receptors are members of the G-protein coupled receptor superfamily of integral membrane proteins which bind the neuropeptides B and W. These receptors are predominantly expressed in the CNS and have a number of functions including regulation of the secretion of cortisol.

References

(2003). "Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8". Proc. Natl. Acad. Sci. U.S.A..
(2005). "G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades". J. Clin. Endocrinol. Metab..
(2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". Br. J. Pharmacol..

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g-protein-coupled-receptors

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