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N-Ethyltryptamine

Chemical compound

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N-Ethyltryptamine (NET), also abbreviated as NETP, is a tryptamine that is structurally related to N-methyltryptamine (NMT) and the psychedelic drugs N,N-dimethyltryptamine (DMT) and N,N-diethyltryptamine (DET).

Use and effects

Alexander Shulgin included NET as an entry in his book TiHKAL (Tryptamines I Have Known and Loved). However, he stated that it had been subjected only to modest human trials and that no active dose level had been identified.

Pharmacology

Pharmacodynamics

Target	Affinity (Ki, nM)
5-HT1A	IA
5-HT2A	38 ()
99% ()
SERT	19a (EC50)
	3,862a (EC50)
	6,660a (EC50)
Notes: The smaller the value, the more avidly the drug interacts with the site. Footnotes: a = Neurotransmitter release. Sources:

NET has been found to act as a potent serotonin 5-HT2A receptor full agonist and a selective serotonin releasing agent. It is inactive at the 5-HT1A receptor.

Chemistry

Synthesis

The chemical synthesis of NET has been described.

Analogues

Analogues of NET include N-methyltryptamine (NMT), dimethyltryptamine (DMT), methylethyltryptamine (MET), and diethyltryptamine (DET), among others.

Society and culture

Legal status

Canada

NET is not a controlled substance in Canada as of 2025.

References

[http://www.erowid.org/library/books_online/tihkal/tihkal49.shtml NET Entry in ''TIHKAL'']
(October 2014). "Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes". Psychopharmacology (Berl).
"Controlled Drugs and Substances Act".

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

5-ht2a-agonists n-monoalkyltryptamines serotonin-receptor-agonists serotonin-releasing-agents tihkal

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