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Muromegalovirus

Genus of viruses

Muromegalovirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Betaherpesvirinae. Rodents serve as natural hosts. There are three species in this genus. Diseases associated with this genus include: infected peritoneal macrophages, dendritic cells (DC) and hepatocytes, inducing significant pathology in both the spleen and the liver. Murid viruses Murid betaherpesvirus 1 (MuHV-1) and Murid betaherpesvirus 2 (MuHV-2), previously defined as mouse cytomegalovirus (MCMV) and rat cytomegalovirus (RCMV), belong to this genus.

Species

The following 3 species are assigned to the genus in ICTV 2022:

Muromegalovirus muridbeta1
Muromegalovirus muridbeta2
Muromegalovirus muridbeta8

Structure

Viruses in Muromegalovirus are enveloped, with icosahedral, spherical to pleomorphic, and round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented, around 230kb in length.

Genus	Structure		Symmetry	Capsid	Genomic arrangement	Genomic segmentation
Muromegalovirus	Spherical pleomorphic	T=16	Enveloped	Linear

Life cycle

Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachment of the viral glycoproteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA-templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear egress, and budding. Rodents serve as the natural host.

Genus	Host details	Tissue tropism	Entry details	Release details	Replication site	Assembly site	Transmission
Muromegalovirus	Rodents	Salivary glands	Glycoprotiens	Budding	Nucleus	Nucleus	Contact

References

"Viral Zone". ExPASy.
(March 2023). "Virus Taxonomy: 2022 Release". International Committee on Taxonomy of Viruses (ICTV).
(2007). "Human herpesviruses: biology, therapy, and immunoprophylaxis". Cambridge University Press.

Info: Wikipedia Source

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betaherpesvirinae animal-viral-diseases virus-genera rodent-diseases

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