Mount Sinai Hospital (Manhattan)

History

Early years

At the time of the founding of the hospital in 1852, other hospitals in New York City discriminated against Jewish people by either not hiring doctors or nurses to treat patients and by prohibiting them from being treated in the hospitals' wards. Orthodox Jewish philanthropist Sampson Simson (1780–1857) founded the hospital to address the needs of New York City's rapidly growing Jewish immigrant community. It was the second Jewish hospital in the United States, after the Jewish Hospital, located in Cincinnati, Ohio, which was established in 1847.

The Jews' Hospital in the City of New York, as it was called until adopting its current name in 1866, was built on West 28th Street in Manhattan, between Seventh and Eighth Avenues, on land donated by Simson. It opened two years before Simson's death. Four years later, it was unexpectedly filled to capacity with soldiers injured in the American Civil War.

The Jews' Hospital felt the effects of the escalating Civil War in other ways, as staff doctors and board members were called into service. Dr. Israel Moses served four years as lieutenant colonel in the 72nd New York Infantry Regiment; Joseph Seligman had to resign as a member of the board of directors, as he was increasingly called upon by President Lincoln for advice on the country's growing financial crisis.

The New York Draft Riots of 1863 also strained the hospital's resources, as it struggled to tend to the many wounded.

More and more, the Jews' Hospital was finding itself an integral part of the general community. In 1866, to reflect this new-found role, it changed its name to Mount Sinai Hospital. In 1872, the hospital moved uptown to the east side of Lexington Avenue between East 66th and 67th streets.

20th century

Now called Mount Sinai Hospital, the institution forged relationships with many physicians who made contributions to medicine, including Henry N. Heineman, Frederick S. Mandelbaum, Bernard Sachs, Charles A. Elsberg, Emanuel Libman, and, most significantly, Abraham Jacobi, known as the father of American pediatrics and a champion of construction at the hospital's new site on Manhattan's Upper East Side in 1904.

The hospital established a school of nursing in 1881. Created by Alma deLeon Hendricks and a small group of women, Mount Sinai Hospital Training School for Nurses was taken over by the hospital in 1895. In 1923, its name was changed to Mount Sinai Hospital School of Nursing. This school closed in 1971 after graduating 4,700 women and one man in the last class. An active alumnae association continues to exist. Since 2013, the nursing school of the Mount Sinai Health System has been called Mount Sinai Phillips School of Nursing (PSON).

The early 20th century saw the population of New York City explode. That, coupled with many new discoveries at Mount Sinai (including significant advances in blood transfusions and the first endotracheal anesthesia apparatus), meant that Mount Sinai's pool of doctors and specialists was in increasing demand. A $1.35 million ($ in current dollar terms) expansion of the 1904 hospital site raced to keep pace with demand. The opening of the new buildings was delayed by the advent of World War I. Mount Sinai responded to a request from the United States Army Medical Corps with the creation of Base Hospital No.3. This unit went to France in early 1918, and treated 9,127 patients with 172 deaths: 54 surgical and 118 medical, the latter due mainly to influenza and pneumonia.

World War II

Two decades later, with tensions in Europe escalating, a committee dedicated to finding placements for doctors fleeing Nazi Germany was founded in 1933. With the help of the National Committee for the Resettlement of Foreign Physicians, Mount Sinai Hospital became a new home for a large number of émigrés. When World War II broke out, Mount Sinai was the first hospital to throw open its doors to Red Cross nurses' aides; the hospital trained many in its effort to reduce the nursing shortage in the United States. Meanwhile, the president of the medical board, George Baehr, M.D., was called by President Roosevelt to serve as the nation's chief medical director of the Office of Civilian Defense.

These wartime roles were eclipsed, however, when the men and women of Mount Sinai's 3rd General Hospital set sail for Casablanca, Morocco, eventually setting up a 1,000-bed hospital in war-torn Tunisia. Before moving to tend to the needs of soldiers in Italy and France, the 3rd General Hospital had treated more than 5,000 wounded soldiers.

Postwar

In 1963, the hospital created a medical school, and in 1968, it welcomed the first students of the Mount Sinai School of Medicine, now the Icahn School of Medicine at Mount Sinai. The 1980s had a $500 million hospital expansion, including the construction of the Guggenheim Pavilion, the first medical facility designed by I.M. Pei. Its faculty has made significant contributions to gene therapy, cardiology, immunotherapy, organ transplants, cancer treatments, and minimally invasive surgery.

Among the innovations at Mount Sinai were performing the first blood transplant into the vein of a fetus in 1986, and the development of a technique for inserting radioactive seeds into the prostate to treat cancer in 1995.

21st century

Milestones

2000s

• At Mount Sinai the staff performed the first successful composite tracheal transplant, which was performed at the hospital in 2005.
• First gene variant linked to autism identified.
• Zahi Fayad, PhD, and Valentin Fuster, MD, PhD, develop a technique called “black blood MRI” to detect vulnerable arterial plaque.
• Published the first medical publication along with Case Western Reserve University School of Medicine, antiretroviral treatments for HIV+ patients with renal failure.
• Bruce Gelb, MD, with collaborators, co-discovers that mutations in PTPN11 cause Noonan syndrome, inaugurating the Ras/MAPK “RASopathies” disease family.
• Fabrazyme approved by FDA to treat Fabry disease, developed by Robert Desnick, PhD, MD, David Bishop, PhD, and Yiannis Ioannou, PhD.
• First successful composite tracheal transplant is performed by Eric Genden, MD, using tissue from a donor and the recipient.
• 1918 flu virus reconstructed by Adolfo García-Sastre, Peter Palese and colleagues for modern research.
• OLIG2 gene linked to schizophrenia is discovered.
• Proteins associated with ALS are identified in cerebrospinal fluid.
• Advanced imaging of leukocyte microdomains (white blood cell movement) developed.
• Standard definitions for bleeding in trials established by Roxana Mehran, MD. 2010s
• In January 2013 David L. Reich was the first openly gay medical doctor named interim president of Mount Sinai Hospital as reported by The New York Times. In October of the same year he was named president.
• Mechanism for a Parkinson’s gene mutation uncovered.
• Vivek Reddy, MD implanted the first U.S. leadless cardiac pacemaker (St. Jude/Abbott Nanostim), launching the LEADLESS II pivotal trial.
• First U.S. use of an FDA-approved drug-coated balloon for leg arteries.
• Saadi Ghatan, MD, and team implant the NeuroPace RNS® system in a 14-year-old—then the youngest patient treated with this device—helping establish pediatric use of RNS for drug-resistant epilepsy.
• May, 20215 Kidney Stone Center opens for advanced and preventive care.
• First HIV-positive–to–HIV-positive organ transplant in New York State, performed by Sander Florman, MD, and Susan Lerner, MD.
• First tau-PET pattern of CTE reported in a living person. reavealing a CTE-typical tau pattern in a former NFL player—an early step toward in-life detection of the disease.
• Immune map of eczema by Emma Guttman, MD, PhD, and colleagues guides a breakthrough therapy.
• Two strains of human herpesvirus are found in the brains of people with Alzheimer’s disease at levels up to twice as high as in those without Alzheimer’s, as shown by Joel Dudley, PhD, and Samuel Gandy, MD, PhD. 2020s
• Dr. David Reich, president and COO of the hospital, announced in March 2020 that the hospital was converting its lobbies into extra patient rooms to "meet the growing volume of patients" that contracted COVID-19.
• Florian Krammer, PhD, and Viviana Simon, MD, PhD, lead a team that develops, validates, and launches a test that detects the quantity as well as the presence or absence of antibodies to SARS-CoV-2.
• Common prostate cancer gene fusion identified, ransforming diagnosis and research into disease subtypes.
• Gustave L. Levy Stroke Unit earns certification as Comprehensive Stroke Center.
• Mount Sinai doctors performed the first liver transplant in the US for a patient with acute intermittent porphyria.
• Institute for Health Equity Research established.

Recent acknowledgments

2024

• Becker's Great Hospitals in America, 2024
• Lown Institute's 2024-2025 Honor Roll
• Healthgrades' Top 10% of U.S. Hospitals for Patient Safety in 2024
• Mount Sinai Doctors' Samuel J. Friedman Health Center for the Performing Arts, 2024 Tony Honor for Excellence in Theatre
• Valentin Fuster, MD, PhD, The World Heart Federation's Lifetime Achievement Award for 2024
• Beth Oliver, Modern Healthcare's 50 Most Influential Clinical Executives
• Mount Sinai Morningside, Mount Sinai South Nassau, and Mount Sinai West, The Emergency Nurses Association's Top 94 emergency departments across the U.S.
• The Emergency Nurses Association's 2024 Lantern Award®
• Emma Guttman, European Academy of Allergy & Clinical Immunology's Paul Ehrlich Award for Experimental Research

2025

• Brendan G. Carr and Jared Kutzin, Becker's Great Leaders in Healthcare
• Mount Sinai Morningside, MSSN, and Mount Sinai Hospital, American Heart Association's Commitment to Quality Award
• Emergency departments at Mount Sinai Brooklyn and Mount Sinai Queens, Emergency Nurse Association's Lantern Award®
• Fanny Elahi,Women's Health Longevity Redefiners
• Alon Harris, The Glaucoma Foundation's Robert Ritch Award for Innovation and Excellence in Glaucoma
• Franco Izzo, American Society of Hematology's 2025 Scholar Award Recipients
• Lauren Singelakis, Women We Admire's Top 50 Women Leaders in Medicine for 2025

Controversies

• Dr. Jack M. Gorman, formerly Department Chairman of Psychiatry at Mount Sinai, engaged in a long-term inappropriate sexual relationship with a patient prior to October 2005.
• In August 2016, Dennis S. Charney, then dean of the medical school, was shot and wounded as he left a deli in his home town of Chappaqua, New York. Hengjun Chao, a former Mount Sinai medical researcher who had been fired by Charney for research misconduct in 2010, was convicted of attempted second degree murder and two other charges in 2017, and received a sentence of 28 years.
• In 2017, Dr. David H. Newman, a former emergency room physician at Mount Sinai Hospital, was sentenced to two years in prison for sexually abusing four female patients in the emergency room between 2015 and 2016, including touching their breasts.
• Three doctors were convicted of violating anti-kickback laws by accepting bribes disguised as speaker fees to write prescriptions to a highly addictive fentanyl opioid painkiller. Gordon Freedman, an anesthesiologist at Mount Sinai, was convicted in December 2019 in Manhattan federal court. Alexandru Burducea, a pain management doctor and anesthesiologist who previously worked at Mount Sinai, was sentenced in January 2020 to 57 months in prison. Dialecti Voudouris, who specialized in oncology and hematology at Lenox Hill Hospital and Mount Sinai, was sentenced in 2020 to time served.
• In April 2019, a lawsuit was filed against Mount Sinai Health System and several employees of the hospital and the Icahn School's Arnhold Institute for Global Health. The suit was filed by eight current and former doctors and employees for alleged age and sex discrimination and based on a list of other allegations. The school denied the claims.

Mount Sinai Kravis Children's Hospital

Main article: Mount Sinai Kravis Children's Hospital

Mount Sinai Kravis Children's Hospital (KCH) at Mount Sinai is a nationally ranked pediatric acute care children's hospital located at the Mount Sinai campus in Manhattan, New York City, New York. The hospital has 102 pediatric beds. It is affiliated with The Icahn School of Medicine at Mount Sinai, and is a member of the Mount Sinai Health System. The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21 throughout the region.

Employment

As of 2025, the entire Mount Sinai Health System had over 9,000 physicians, 2,700 residents and clinical fellows, and 48,000 employees, as well as 3,221 beds and 140 operating rooms, and delivered over 13,940 babies a year.

Affiliates

Mount Sinai has a number of hospital affiliates in the New York metropolitan area, including Brooklyn Hospital Center and an additional campus, Mount Sinai Hospital of Queens. The hospital is also affiliated with the Icahn School of Medicine at Mount Sinai, which opened in September 1968. In 2013, Mount Sinai Hospital joined with Continuum Health Partners in the creation of the Mount Sinai Health System. The system encompasses the Icahn School of Medicine at Mount Sinai and seven hospital campuses in the New York metropolitan area, as well as a large, regional ambulatory footprint.

Rankings

In March 2025, the hospital was ranked 19th among over 2,400 hospitals in the world and the best hospital in New York state by Newsweek.

In 2025-2026, Mount Sinai Hospital was recognized on the U.S. News & World Report "Best Hospitals Honor Roll," with multiple specialties ranked in the top 20 nationwide (cardiology #2, geriatrics #3, gastroenterology #5, cancer #6, urology #6, neurology & neurosurgery #11, orthopedics #14, obstetrics & gynecology #17, diabetes & endocrinology #19).

Notable individuals

Benefactors

• Leon Black donated $10 million in 2005 to create the Black Family Stem Cell Institute.
• Emily and Len Blavatnik made a $10 million gift in 2018 to establish The Blavatnik Family Women's Health Research Institute at the Icahn School of Medicine at Mount Sinai and The Blavatnik Family – Chelsea Medical Center at Mount Sinai.
• Carl Icahn donated $25 million to Mount Sinai Medical Center for advanced medical research in 2004; a large building primarily devoted to research was renamed from the "East Building" to the "Icahn Medical Institute." In 2012, Icahn pledged $200 million to the institution. In exchange, the medical school was renamed the Icahn School of Medicine at Mount Sinai and the genomics institute led by Eric Schadt was renamed the Icahn Institute for Genomics and Multiscale Biology.
• Frederick Klingenstein, former CEO of Wertheim & Co., and wife Sharon Klingenstein donated $75 million in 1999 to the medical school, the largest single gift in the history of Mount Sinai medical school at the time, to establish an institute for scientific research and create a scholarship fund.
• Henry Kravis and wife Marie-Josée Kravis donated $15 million to establish the "Center for Cardiovascular Health" as well as funding a professorship.
• Samuel A. Lewis, NYC political leader and philanthropist who served for 21 years (1852–1873) as the first director, then honorary secretary, and finally chairman of the executive committee.
• Hermann Merkin gave $2 million in dedication of the kosher kitchen at the hospital.
• Derald Ruttenberg donated $7 million in 1986 to establish the Ruttenberg Cancer Center at Mount Sinai and later contributed $8 million more.
• Martha Stewart donated $5 million in 2007 to start the Martha Stewart Center for Living at Mount Sinai Hospital. The center promotes access to medical care and offers support to caregivers needing referrals or education.
• James Tisch and wife Merryl Tisch donated $40 million in 2008 to establish The Tisch Cancer Institute, a state-of-the-art, patient-oriented comprehensive cancer care and research facility.

Staff

• Jacob M. Appel (born 1973), bioethicist and liberal commentator
• Mark Blumenthal (1831–1921), resident and attending physician of Mount Sinai Hospital from 1854 to 1859
• Deepak L. Bhatt, first director of the Mount Sinai Fuster Heart Hospital
• Burrill Bernard Crohn (1884–1983), gastroenterologist and one of the first to describe the disease of which he is the namesake, Crohn's disease.
• Sander S. Florman, director of Recanati/Miller Transplant Institute.
• Valentín Fuster (born 1943), director of Mount Sinai Heart, The Zena and Michael A. Wiener Cardiovascular Institute, The Marie-Josée and Henry R. Kravis Center for Cardiovascular Health, The Richard Gorlin, MD/Heart Research Foundation Professor, Icahn School of Medicine at Mount Sinai.
• Eric M. Genden, Isidore Friesner Professor and Chair of Otolaryngology – Head and Neck Surgery, Senior Associate Dean for Clinical Affairs, and Professor of Neurosurgery and Immunology at the Icahn School of Medicine at Mount Sinai. He is Chair of Otolaryngology – Head and Neck Surgery, Executive Vice President of Ambulatory Surgery, and Director of the Head and Neck Institute at the Mount Sinai Health System. Named one of the most innovative surgeons alive today, in 2006 he became the first surgeon ever to perform a successful jaw transplant.
• Irving B. Goldman (1898–1975), first president of the American Academy of Facial Plastic and Reconstructive Surgery, 1964.
• Jonathan L. Halperin (born 1949), director of Clinical Cardiology in the Zena and Michael A. Wierner Cardiovascular Institute.
• Michael Heidelberger (1888–1991), immunologist regarded as the father of modern immunology.
• Abraham Jacobi (1830–1919), pediatrician and president of the American Medical Association. Pioneer of pediatrics In the US, devoted to women's and children's welfare.
• Eimear Kenny, known for novel approaches to computational genomics that examine human genetic variation and its link to disease, thereby laying the groundwork for integrating AI and genomics into routine clinical care.
• I. Michael Leitman (born 1959), American surgeon and medical educator.
• Blair Lewis (born 1956), gastroenterologist who helped develop the American Gastroenterological Association's position statement on occult and obscure gastrointestinal bleeding.
• Helen S. Mayberg (born 1956), founding director of the Center for Advanced Circuit Therapeutics.
• John Puskas, performed the first totally thoracoscopic bilateral pulmonary vein isolation procedure.
• David L. Reich, academic anesthesiologist, president and chief operating officer of Mount Sinai, chair of the department of anesthesiology, Horace W. Goldsmith Professor of Anesthesiology.
• Isidor Clinton Rubin (1883–1958), gynecologist and infertility specialist.
• Jonas Salk (1914–1995), inventor of the polio vaccine, worked as a staff physician at Mount Sinai after medical school.
• Milton Sapirstein (1914–1996), clinical psychiatrist. Sought "to mesh the advances being made in neurobiology in the 1940s with psychoanalytic concepts."
• Samin Sharma (born 1955), interventional cardiologist,  co-founder of the Eternal Heart Care Centre and Research Institute, Jaipur, and director, Dr. Samin K. Sharma Family Foundation Cardiac Catheterization Laboratory.
• Larry J. Siever (1947–2021), psychiatrist known for his work in studying personality disorders.

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