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Mir-449 microRNA precursor family

FieldValue
NamemiR-449
SymbolmiR-449
RfamRF00711
miRBase_familyMIPF0000133
RNA_typemicroRNA
Tax_domainEukaryota;

In molecular biology, microRNAs function to regulate the expression levels of other genes by several mechanisms. The miR-449 microRNA family encompasses three homologous small RNA molecules (miR-449a/b/c). This miR-449 cluster is located in the second intron of the CDC20B gene which both are co-transcribed. This miR-449 family belongs to the miR-34/miR-449 superfamily of microRNAs that is composed of six homologous miRNAs, named miR-34a/b/c and miR-449a/b/c. They are grouped together in the same superfamily, as their seed region and their adjacent nucleotide sequences are largely conserved. The miR-449 miRNAs control the differentiation of multiciliated cells in vertebrates.

References

References

  1. Marcet B, Chevalier B, Luxardi G, Coraux C, Zaragosi LE, Cibois M, Robbe-Sermesant K, Jolly T, Cardinaud B, Moreilhon C, Giovannini-Chami L, Nawrocki-Raby B, Birembaut P, Waldmann R, Kodjabachian L, Barbry P.. (2011). ""Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway".". [[Nature Cell Biology]].
  2. Ioannis Loukas, Margarita Skamnelou, Stavroula Tsaridou, Spyridoula Bournaka, Sokratis Grigoriadis, Stavros Taraviras, Zoi Lygerou and Marina Arbi. (2021). "Fine-tuning multiciliated cell differentiation at the post-transcriptional level: contribution of miR-34/449 family members". [[Biological Reviews]].
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