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MiR-338

Family of brain-specific microRNA precursors

Summary

Family of brain-specific microRNA precursors

FieldValue
NamemiR-338
imageMir-338 SS.png
captionConserved secondary structure of miR-338 microRNA precursor
SymbolmiR-338
AltSymbolsMIR338
RfamRF00686
miRBaseMI0000814
miRBase_familyMIPF0000097
RNA_typemiRNA
Tax_domainMammalia
GO0035195
SO0001244
EntrezGene442906
HGNCid31775
OMIM614059
RefSeqNR_029897
Chromosome17
Armq
Band25.3

miR-338 is a family of brain-specific microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference.

miR-338 is located in an intronic region within the gene for apoptosis-associated tyrosine kinase (AATK). It has been predicted that it may downregulate genes which have a downstream negative effect on AATK expression.

Function

miR-338 is a brain-specific miRNA which regulates the expression of cytochrome c oxidase IV (COX4). The mature miR-338 miRNA sequence is complementary to a short section of the 3' untranslated region of COX4 mRNA. This mRNA sequence is presented atop a stem-loop structure, indicating it is accessible to miRNA processing.

Applications

miR-338 is dysregulated in neuroblastoma, and could potentially be implemented as a biomarker or future therapeutic agent. miR-338 has also been linked with hepatocellular carcinoma, and a large-scale diagnostic test has been suggested involving measurement of miR-338 expression in tissue samples. Furthermore, miR-338 is one of seven microRNAs whose expression profiles can be combined to give a prediction of the probability of survival of a patient with gastric cancer.

References

References

  1. (Nov 2008). "MicroRNA-338 regulates local cytochrome c oxidase IV mRNA levels and oxidative phosphorylation in the axons of sympathetic neurons". The Journal of Neuroscience.
  2. (Dec 2001). "microRNAs: tiny regulators with great potential". Cell.
  3. (Nov 2005). "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing". Cell.
  4. (Sep 2008). "An intronic microRNA silences genes that are functionally antagonistic to its host gene". Nucleic Acids Research.
  5. (2009). "Cell Biology of the Axon".
  6. (Oct 2010). "MIR152, MIR200B, and MIR338, human positional and functional neuroblastoma candidates, are involved in neuroblast differentiation and apoptosis". Journal of Molecular Medicine.
  7. (Aug 2009). "Bead-based microarray analysis of microRNA expression in hepatocellular carcinoma: miR-338 is downregulated". Hepatology Research.
  8. (May 2010). "Survival prediction of gastric cancer by a seven-microRNA signature". Gut.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

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