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MiR-33

Non-coding RNA in the species Homo sapiens

Summary

Non-coding RNA in the species Homo sapiens

FieldValue
NamemiR-33a
imageMir-33 SS.png
captionConserved secondary structure of miR-33a microRNA precursor
SymbolmiR-33a
AltSymbolsmir33a
RfamRF00667
miRBaseMI0000091
miRBase_familyMIPF0000070
RNA_typemiRNA
Tax_domainMetazoa
GO0035195
SO0001244
EntrezGene407039
HGNCid31634
Chromosome22
Armq
Band13.2

miR-33 is a family of microRNA precursors, which are processed by the Dicer enzyme to give mature microRNAs. miR-33 is found in several animal species, including humans. In some species there is a single member of this family which gives the mature product mir-33. In humans there are two members of this family called mir-33a and mir-33b, which are located in intronic regions within two protein-coding genes for Sterol regulatory element-binding proteins (SREBP-2 and SREBP-1) respectively.

Function

miR-33 plays a role in lipid metabolism; it downregulates a number of ABC transporters, including ABCA1 and ABCG1, which in turn regulate cholesterol and HDL generation. Further related roles of miR-33 have been proposed in fatty acid degradation and in macrophage response to low-density lipoprotein. It has been suggested that miR-33a and miR-33b regulates genes Involved in fatty acid metabolism and insulin signalling.

Potential binding sites for mir-33 have been identified in the cDNA of tumour suppressor p53. Further, study has shown that miR-33 is able to repress p53 expression and p53-induced apoptosis. This function is thought to be related to hematopoietic stem cell renewal.

Applications

miR-33, along with miR-122, could be used to diagnose or treat conditions related to metabolic disorders and cardiovascular disease.

References

References

  1. Ambros, V. (2001). "microRNAs: tiny regulators with great potential". Cell.
  2. Najafi-Shoushtari, SH. (Jun 2011). "MicroRNAs in cardiometabolic disease.". Current Atherosclerosis Reports.
  3. Fernández-Hernando, C. (Apr 2011). "MicroRNAs in lipid metabolism.". Current Opinion in Lipidology.
  4. Moore, KJ. (Dec 2010). "microRNAs and cholesterol metabolism.". Trends in Endocrinology and Metabolism.
  5. (May 2011). "miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling". Proc. Natl. Acad. Sci. U.S.A..
  6. Herrera-Merchan, A. (Aug 15, 2010). "miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal.". Cell Cycle.
  7. Fuster, JJ. (Sep 1, 2010). "A role for miR-33 in p53 regulation: New perspectives for hematopoietic stem cell research.". Cell Cycle.
  8. Najafi-Shoushtari, SH. (Jun 18, 2010). "MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis.". Science.
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This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

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