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MiR-208

Field	Value
Name	miR-208
image	Mir-208 SS.png
caption	Conserved secondary structure of miR-208 microRNA precursor
Symbol	miR-208
AltSymbols	MIR208
Rfam	RF00749
miRBase	MI0000251
miRBase_family	MIPF0000178
RNA_type	miRNA
Tax_domain	Metazoa
GO	0035195
SO	0001244
EntrezGene	406990
HGNCid	31585
OMIM	611116
RefSeq	NR_029595
Chromosome	14
Arm	q
Band	11.2

miR-208 is a family of microRNA precursors found in animals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference.

In humans, the gene for miR-208 is located in an intron of MYH7.

Function

miR-208 has been deemed a "myomiR" as it is specifically expressed, or found at much higher levels, in cardiac tissue. Other myomiRs include miR-1 and miR-133. miR-208 is thought to be dysregulated in various cardiovascular diseases.

miR-208 functions in cardiomyocytes regulating the production of the myosin heavy chain during development. It also responds to stress and forms part of a hormonal signalling cascade in cardiac cells.

Applications

A preliminary study has shown a potential use in the prognosis of dilated cardiomyopathy. Another application has been suggested as using plasma concentration of miR-208 as a biomarker of damaged cardiac muscle cells.

References

(December 2001). "microRNAs: tiny regulators with great potential". Cell.
(November 2005). "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing". Cell.
(Mar–Apr 2011). "MicroRNAs in cardiomyocyte development". Wiley Interdisciplinary Reviews: Systems Biology and Medicine.
(2010). "The roles of microRNAs in heart diseases: a novel important regulator". Current Medicinal Chemistry.
(May 2011). "MicroRNAs in the cardiovascular system". Current Opinion in Cardiology.
(April 2007). "Control of stress-dependent cardiac growth and gene expression by a microRNA". Science.
(May 2010). "Expression of microRNA-208 is associated with adverse clinical outcomes in human dilated cardiomyopathy". Journal of Cardiac Failure.
(November 2009). "Plasma miR-208 as a biomarker of myocardial injury". Clinical Chemistry.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

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