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Mir-145

Non-coding RNA in the species Homo sapiens

Summary

Non-coding RNA in the species Homo sapiens

In molecular biology, mir-145 microRNA is a short RNA molecule that in humans is encoded by the MIR145 gene. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Targets

MicroRNAs are involved in down-regulation of a variety of target genes. Götte et al. have shown that experimental over-expression of mir-145 down-regulates the junctional cell adhesion molecule JAM-A as well as the actin bundling protein fascin in breast cancer and endometriosis cells, resulting in a reduction of cell motility. Larsson et al. showed that miR-145 targets the 3' UTR of the FLI1 gene, a finding that was later supported by Zhang et al.

Role in cancer

miR-145 is hypothesised to be a tumor suppressor. miR-145 has been shown to be down-regulated in breast cancer. miR-145 is also involved in colon cancer and acute myeloid leukemia.

References

References

  1. "Entrez Gene: MicroRNA 145".
  2. (2013). "MicroRNA miR-145 inhibits proliferation, invasiveness, and stem cell phenotype of an in vitro endometriosis model by targeting multiple cytoskeletal elements and pluripotency factors.". Fertility and Sterility.
  3. (Dec 2010). "miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness". Oncogene.
  4. (Nov 2009). "Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1". Genome Medicine.
  5. (Mar 2009). "p53 represses c-Myc through induction of the tumor suppressor miR-145". Proceedings of the National Academy of Sciences of the United States of America.
  6. (Jan 2011). "Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene". Cancer.
  7. (2007). "Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer". Oncology.
  8. (2016-05-19). "Multifaceted enrichment analysis of RNA-RNA crosstalk reveals cooperating micro-societies in human colorectal cancer". Nucleic Acids Research.
  9. (Jan 2011). "Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations". Blood.
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