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MiR-144

Family of microRNA precursors

Summary

Family of microRNA precursors

FieldValue
NamemiR-144
imageMir-144 SS.png
captionConserved secondary structure of miR-144 precursor microRNA
SymbolmiR-144
AltSymbolsMIR144
RfamRF00682
miRBaseMI0000460
miRBase_familyMIPF0000093
RNA_typemiRNA
Tax_domainMammalia
GO0035195
SO0001244
EntrezGene406936
HGNCid31531
OMIM612070
RefSeqNR_029685
Chromosome17
Armq
Band11.2

miR-144 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. In humans, miR-144 has been characterised as a "common miRNA signature" of a number of different tumours.

GATA4 is thought to activate transcription of the miR-144 microRNA precursor.

Function

miR-144 functions in a cluster with miR-451. This locus regulates the expression of a number of genes whose products are involved in erythropoiesis. One of the identified targets of miR-144 is insulin receptor substrate 1.

Applications

miR-144 has been identified as one of a number of potential miRNA targets which could be used to treat schizophrenia and bipolar affective disorder. It has also been suggested as a potential therapeutic tool to treat ischemic heart disease.

References

References

  1. (Dec 2001). "microRNAs: tiny regulators with great potential". Cell.
  2. (Oct 2011). "Human tumor microRNA signatures derived from large-scale oligonucleotide microarray datasets". International Journal of Cancer.
  3. (Nov 2010). "Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death". Journal of Molecular and Cellular Cardiology.
  4. (Jul 2010). "The miR-144/451 locus is required for erythroid homeostasis". The Journal of Experimental Medicine.
  5. (2011). "MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus". PLOS ONE.
  6. (Apr 2010). "MicroRNAs as a target for novel antipsychotics: a systematic review of an emerging field". The International Journal of Neuropsychopharmacology.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

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