Surf Wiki
Save to docs
general/microrna

From Surf Wiki (app.surf) — the open knowledge base

MiR-134

Family of microRNA precursors

Summary

Family of microRNA precursors

FieldValue
NamemiR-134
imageMir-134 SS.png
captionConserved secondary structure of miR-134
Symbolmir-134
AltSymbolsMIR134
RfamRF00699
miRBaseMI0000474
miRBase_familyMIPF0000112
Tax_domainMammalia
GO0035195
SO0001244
EntrezGene406924
HGNCid31519
Chromosome14

miR-134 is a family of microRNA precursors found in mammals, including humans. MicroRNAs are typically transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. The excised region or, mature product, of the miR-134 precursor is the microRNA mir-134.

miR-134 was one of a number of microRNAs found to be increasingly expressed in schizophrenia.

Functions

miR-134 is a brain-specific microRNA; in rats it is localised specifically in hippocampal neurons and may indirectly regulate synaptic development through antisense pairing with LIMK1 mRNA. In the human brain, SIRT1 is thought to mediate CREB protein through miR-134, giving the microRNA a role in higher brain functions such a memory formation.

miR-134 has also been reported to function in mouse embryonic stem cells as part of a complex network regulating their differentiation.

Applications

miR-134 levels in circulating blood could potentially be used as a peripheral biomarker for bipolar disorder.

References

References

  1. (June 2007). "A mammalian microRNA expression atlas based on small RNA library sequencing". Cell.
  2. (December 2001). "microRNAs: tiny regulators with great potential". Cell.
  3. (January 2011). "Upregulation of dicer and microRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia". Biological Psychiatry.
  4. (January 2006). "A brain-specific microRNA regulates dendritic spine development". Nature.
  5. (February 2006). "MicroRNA: microRNAs reach out into dendrites". Current Biology.
  6. (August 2010). "A novel pathway regulates memory and plasticity via SIRT1 and miR-134". Nature.
  7. (January 2008). "MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1". Stem Cells.
  8. (January 2011). "MicroRNA-134 plasma levels before and after treatment for bipolar mania". Journal of Psychiatric Research.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

microrna
Want to explore this topic further?

Ask Mako anything about MiR-134 — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report