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Mir-103/107 microRNA precursor

FieldValue
Namemir-103/107 microRNA precursor
imageRF00129.jpg
captionPredicted secondary structure and sequence conservation of mir-103
Symbolmir-103
RfamRF00129
miRBaseMI0000109
miRBase_familyMIPF0000024
RNA_typeGene; miRNA
Tax_domainEukaryota
GO
SO

The miR-103 microRNA precursor (homologous to miR-107), is a short non-coding RNA gene involved in gene regulation. miR-103 and miR-107 have now been predicted or experimentally confirmed in human.

microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA.

mir-103 and mir-107 were noted as being upregulated in obese mice and were subsequently found to have a key role in insulin sensitivity. This led to a suggestion that these microRNAs represent potential targets for the treatment of type 2 diabetes.

mir-103 has also been linked with chronic pain and intestinal cell proliferation.

Recently, miR-103-3p was shown to target the 5' untranslated region (5' UTR) of GPRC5A's mRNA in pancreatic cancer. This is one of only a handful of known instances where a miRNA targets the 5' UTR of a mRNA.

References

References

  1. (March 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes & Development.
  2. "miRNA gene family: mir-103". University of Manchester.
  3. (December 2001). "microRNAs: tiny regulators with great potential". Cell.
  4. (June 2011). "MicroRNAs 103 and 107 regulate insulin sensitivity". Nature.
  5. (July 2011). "Bidirectional integrative regulation of Cav1.2 calcium channel by microRNA miR-103: role in pain". The EMBO Journal.
  6. (September 2010). "Global microRNA characterization reveals that miR-103 is involved in IGF-1 stimulated mouse intestinal cell proliferation". PLOS ONE.
  7. (September 2014). "MiR-103a-3p targets the 5' UTR of GPRC5A in pancreatic cells". RNA.
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This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

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