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Minretumomab

Monoclonal antibody

Monoclonal antibody

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Minretumomab (CC49) is a mouse monoclonal antibody that was designed for the treatment of cancers that express the TAG-72 antigen. This includes breast, colon, lung, and pancreatic cancers. Apparently, it never got past Phase I clinical trials for this purpose.

Derivatives

A wide range of derivatives has been used in pharmaceutical research. Examples include chimeric and humanized minretumomab, as well as a fusion protein of a minretumomab single-chain variable fragment and the enzyme beta-lactamase.

Radiopharmaceuticals

Iodine (125I) minretumomab is an iodine-125 radiolabelled derivative that was developed for the detection of tumours in radioimmunoassays such as CA 72-4.

Radiolabelled minretumomab has also been tested for the treatment of solid tumours, but without success. Iodine (131I) and lutetium (177Lu) minretumomab, for example, were shown to induce human anti-mouse antibodies; no tumour response was observed in Phase I and II clinical trials.

References

References

  1. (1999). "International Nonproprietary Names for Pharmaceutical Substances (INN)". WHO Drug Information.
  2. (2011-02-02). "TAG-72 antigen". National Cancer Institute.
  3. (March 2012). "Antibody therapy of cancer". Nature Reviews. Cancer.
  4. "Studies found for: CC49". ClinicalTrials.gov.
  5. (February 2010). "Improved efficacy of alpha-particle-targeted radiation therapy: dual targeting of human epidermal growth factor receptor-2 and tumor-associated glycoprotein 72". Cancer.
  6. (2006). "Characterization of a CC49-based single-chain fragment-beta-lactamase fusion protein for antibody-directed enzyme prodrug therapy (ADEPT)". Bioconjugate Chemistry.
  7. (November 1996). "Correlation between tumor-associated glycoprotein 72 mucin levels in tumor and serum of colorectal patients as measured by the quantitative CA 72-4 immunoassay". Cancer Research.
  8. (2001). "Biotherapy". Jones and Bartlett.
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