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MicX sRNA

FieldValue
NameMicX Vibrio cholerae sRNA
imageMicX_SScons.png
captionSecondary structure of MicX sRNA.
SymbolMicX
RfamRF01808
RNA_typesRNA
Tax_domainVibrio cholerae

MicX sRNA (formerly known as A10) is a small non-coding RNA found in Vibrio cholerae. It was given the name MicX as it has a similar function to MicA, MicC and MicF in E. coli. MicX sRNA negatively regulates an outer membrane protein (coded for by VC0972) and also a component of an ABC transporter (gene VC0620). These interactions were predicted and then confirmed using a DNA microarray.

MicX was identified through a bioinformatics screen of V. cholerae having been previously predicted. Levels of transcription of this sRNA were compared under several conditions: it was found to be expressed on all tested mediums; richer mediums slightly reduced transcription; repression of certain sigma factors (δS and δE) did not change transcription but it was dramatically reduced in the absence of Hfq protein. This observation is in accordance with other sRNA expression patterns.

The MicX RNA gene overlaps with VCA0943 - a gene coding for a maltose transporter permease - but the ribonuclease RNAase E processes the MicX transcript to create an active and stable form containing only the VCA0943 3′ UTR.

References

References

  1. (2005). "sRNAPredict: an integrative computational approach to identify sRNAs in bacterial genomes". Nucleic Acids Research.
  2. (July 2007). "RNase E-dependent processing stabilizes MicX, a Vibrio cholerae sRNA". Molecular Microbiology.
  3. (April 1984). "A unique mechanism regulating gene expression: translational inhibition by a complementary RNA transcript (micRNA)". Proceedings of the National Academy of Sciences of the United States of America.
  4. (October 2008). "A new Vibrio cholerae sRNA modulates colonization and affects release of outer membrane vesicles". Molecular Microbiology.
  5. (March 2001). "Hfq is necessary for regulation by the untranslated RNA DsrA". Journal of Bacteriology.
  6. (October 2003). "Coupled degradation of a small regulatory RNA and its mRNA targets in Escherichia coli". Genes & Development.
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