From Surf Wiki (app.surf) — the open knowledge base
Metanephrogenic blastema
Embryological structure involved in the formation of the kidneys
Embryological structure involved in the formation of the kidneys
| Field | Value |
|---|---|
| Name | Metanephrogenic blastema |
| Latin | blastema metanephrogenicum |
| Days | 35 |
| CarnegieStage | 14 |
| Precursor | Wolffian duct |
| GivesRiseTo | Nephron (Bowman's capsule, connecting tubule, distal convoluted tubule, glomerulus, loop of Henle, proximal convoluted tubule), but not collecting duct |
The metanephrogenic blastema or metanephric blastema (or metanephric mesenchyme, or metanephric mesoderm) is one of the two embryological structures that give rise to the kidney, the other being the ureteric bud.
The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.
The system of tissue induction between the ureteric bud and the metanephric blastema is a reciprocal control system. GDNF, glial cell-derived neurotrophic factor, is produced by the metanephric blastema and is essential in binding to the RET receptor on the ureteric bud, which bifurcates and coalesces as a result to form the renal pelvis, major and minor calyces and collecting ducts. Mutations in the EYA1 gene, whose product regulates GDNF expression in the developing kidney, lead to the renal abnormalities of BOR syndrome (branchio-oto-renal syndrome).
References
References
- (1998). "The RET–Glial Cell-derived Neurotrophic Factor (GDNF) Pathway Stimulates Migration and Chemoattraction of Epithelial Cells". Journal of Cell Biology.
- (2004). "SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes". Proceedings of the National Academy of Sciences.
This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.
Ask Mako anything about Metanephrogenic blastema — get instant answers, deeper analysis, and related topics.
Research with MakoFree with your Surf account
Create a free account to save articles, ask Mako questions, and organize your research.
Sign up freeThis content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.
Report