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Membrane-type matrix metalloproteinase-1

Field	Value
Name	Membrane-type matrix metalloproteinase-1
EC_number	3.4.24.80
CAS_number	161384-17-4

Membrane-type matrix metalloproteinase-1 (, matrix metalloproteinase 14) is an enzyme. This enzyme catalyses the following chemical reaction

: Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37-Leu. Other bonds hydrolysed include Gly35-Ile in the propeptide of collagenase 3, and Asn341-Phe, Asp441-Leu and Gln354-Thr in the aggrecan interglobular domain

This enzyme belongs to peptidase family M10.

References

(September 2001). "Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion". The EMBO Journal.

Wikipedia Source

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ec-3.4.24

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